Efficient Lung Recruitment of Respiratory Syncytial Virus-Specific Th1 Cells Induced by Recombinant Bacillus Calmette-Guerin Promotes Virus Clearance and Protects from Infection
dc.contributor.author | Cautivo, Kelly M. | |
dc.contributor.author | Bueno, Susan M. | |
dc.contributor.author | Cortes, Claudia M. | |
dc.contributor.author | Wozniak, Aniela | |
dc.contributor.author | Riedel, Claudia A. | |
dc.contributor.author | Kalergis, Alexis M. | |
dc.date.accessioned | 2024-01-10T13:47:56Z | |
dc.date.available | 2024-01-10T13:47:56Z | |
dc.date.issued | 2010 | |
dc.description.abstract | Infection by the respiratory syncytial virus (RSV) can cause extensive inflammation and lung damage in susceptible hosts due to a Th2-biased immune response. Such a deleterious inflammatory response can be enhanced by immunization with formalin- or UV-inactivated RSV, as well as with vaccinia virus expressing the RSV-G protein. Recently, we have shown that vaccination with rBCG-expressing RSV Ags can prevent the disease in the mouse. To further understand the immunological mechanisms responsible for protection against RSV, we have characterized the T cell populations contributing to virus clearance in mice immunized with this BCG-based vaccine. We found that both CD4(+) and CD8(+) T cells were recruited significantly earlier to the lungs of infected mice that were previously vaccinated. Furthermore, we observed that simultaneous adoptive transfer of CD8(+) and CD4(+) RSV-specific T cells from vaccinated mice was required to confer protection against virus infection in naive recipients. In addition, CD4(+) T cells induced by vaccination released IFN-gamma after RSV challenge, indicating that protection is mediated by a Th1 immune response. These data suggest that vaccination with rBCG-expressing RSV Ags can induce a specific effector/memory Th1 immune response consisting on CD4(+) and CD8(+) T cells, both necessary for a fully protective response against RSV. These results support the notion that an effective induction of Th1 T cell immunity against RSV during childhood could counteract the unbalanced Th2-like immune response triggered by the natural RSV infection. The Journal of Immunology, 2010, 185: 7633-7645. | |
dc.description.funder | Fondo Nacional de Desarrollo Cientifico y Tecnologico | |
dc.description.funder | International Foundation for Science | |
dc.description.funder | Vicerrectoria Adjunta de Investigacion y Doctorado-Inicio | |
dc.description.funder | Red-15 Programa Bicentenario de Ciencia y Tecnologia | |
dc.description.funder | Millennium Nucleus on Immunology and Immunotherapy | |
dc.fechaingreso.objetodigital | 2024-05-30 | |
dc.format.extent | 13 páginas | |
dc.fuente.origen | WOS | |
dc.identifier.doi | 10.4049/jimmunol.0903452 | |
dc.identifier.eissn | 1550-6606 | |
dc.identifier.issn | 0022-1767 | |
dc.identifier.pubmedid | MEDLINE:21084664 | |
dc.identifier.uri | https://doi.org/10.4049/jimmunol.0903452 | |
dc.identifier.uri | https://repositorio.uc.cl/handle/11534/79318 | |
dc.identifier.wosid | WOS:000284878700062 | |
dc.information.autoruc | Medicina; Wozniak A;S/I;1008612 | |
dc.information.autoruc | Ciencias Biológicas;Bueno S;S/I;113541 | |
dc.information.autoruc | Ciencias Biológicas;Cautivo K;S/I;189036 | |
dc.information.autoruc | Medicina;Cortes CM;S/I;1000888 | |
dc.information.autoruc | Ciencias Biológicas;Kalergis AM ;S/I;90610 | |
dc.information.autoruc | Ciencias Biológicas;Riedel C;S/I;88772 | |
dc.issue.numero | 12 | |
dc.language.iso | en | |
dc.nota.acceso | Contenido parcial | |
dc.pagina.final | 7645 | |
dc.pagina.inicio | 7633 | |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | |
dc.revista | JOURNAL OF IMMUNOLOGY | |
dc.rights | acceso restringido | |
dc.subject | IMMUNIZED BALB/C MICE | |
dc.subject | TUMOR-NECROSIS-FACTOR | |
dc.subject | CD4+ T-CELLS | |
dc.subject | MHC CLASS-II | |
dc.subject | INTERFERON-GAMMA | |
dc.subject | IFN-GAMMA | |
dc.subject | DENDRITIC CELLS | |
dc.subject | RSV VACCINE | |
dc.subject | PULMONARY EOSINOPHILIA | |
dc.subject | PLASMODIUM-CHABAUDI | |
dc.subject.ods | 03 Good Health and Well-being | |
dc.subject.odspa | 03 Salud y bienestar | |
dc.title | Efficient Lung Recruitment of Respiratory Syncytial Virus-Specific Th1 Cells Induced by Recombinant Bacillus Calmette-Guerin Promotes Virus Clearance and Protects from Infection | |
dc.type | artículo | |
dc.volumen | 185 | |
sipa.codpersvinculados | 1008612 | |
sipa.codpersvinculados | 113541 | |
sipa.codpersvinculados | 189036 | |
sipa.codpersvinculados | 1000888 | |
sipa.codpersvinculados | 90610 | |
sipa.codpersvinculados | 88772 | |
sipa.index | WOS | |
sipa.index | Scopus | |
sipa.trazabilidad | Carga SIPA;09-01-2024 |
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