Molecular abnormalities associated with endocrine tumors of the uterine cervix

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dc.contributor.authorWistuba, II
dc.contributor.authorThomas, B
dc.contributor.authorBehrens, C
dc.contributor.authorOnuki, N
dc.contributor.authorLindberg, G
dc.contributor.authorAlbores Saavedra, J
dc.contributor.authorGazdar, AF
dc.date.accessioned2024-01-10T12:40:33Z
dc.date.available2024-01-10T12:40:33Z
dc.date.issued1999
dc.description.abstractObjective. We studied the molecular abnormalities involved in the pathogenesis of endocrine tumors of the uterine cervix.
dc.description.abstractMethods. We obtained DNA from precisely microdissected archival tissue from 15 endocrine tumors of the uterine cervix, consisting of 5 carcinoids (1 typical, 4 atypical), 2 large cell neuroendocrine carcinomas, and 8 small cell carcinomas. We investigated the presence of high-risk (types 16 and 18) and intermediate-risk (types 31 and 33) human papilloma virus (HPV) sequences, TP53 and K-ras gene mutations, and loss of heterozygosity (LOH) at 9 genes/chromosomal regions, including 3p14.2/FHIT, 3p14-p21, 3p21, 3p22-p24, 5q21-q22/APC-MCC region, 9p21/CDKN2, 11q23/MEN1, 13q/RB, and 17p/TP53.
dc.description.abstractResults. HPV sequences were detected in 8 (53%) tumors, HPV 16 in 2 cases, and HPV 18 in 2 cases. LOH at 9p21 (43%) and localized 3p deletions (47%) were the most frequent allelic losses found. Allelic losses at 5q21-q22/APC-MCC region, 11q23/MEN1, and 13q/RB were infrequent. TP53 gene mutations were detected in 7 (47%) tumors (1 atypical carcinoid and 6 carcinomas). HPV sequences were demonstrated in 4 of the 7 cases with TP53 gene mutations. No K-ras mutations were detected.
dc.description.abstractConclusion. The molecular changes present in endocrine tumors of the uterine cervix have distinct features. They incorporate those present in the neuroendocrine tumors of the lung (high frequency of TP53 gene abnormalities and 9p21 deletions) with those detected in squamous cell carcinomas of the cervix (high-risk HPV sequences and localized 3p deletions). (C) 1999 Academic Press.
dc.fechaingreso.objetodigital2024-04-12
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1006/gyno.1998.5248
dc.identifier.eissn1095-6859
dc.identifier.issn0090-8258
dc.identifier.pubmedidMEDLINE:9889022
dc.identifier.urihttps://doi.org/10.1006/gyno.1998.5248
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77322
dc.identifier.wosidWOS:000078147100002
dc.information.autorucMedicina;Wistuba I;S/I;100278
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final9
dc.pagina.inicio3
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.revistaGYNECOLOGIC ONCOLOGY
dc.rightsacceso restringido
dc.subjectneuroendocrine tumors
dc.subjecttumors of the uterine cervix
dc.subjectloss of heterozygosity
dc.subjectchromosome 3p
dc.subjectTP53 gene mutations
dc.subjectSPORADIC GASTRINOMAS
dc.subjectALLELIC LOSS
dc.subjectCARCINOMA
dc.subjectGENE
dc.subjectMUTATIONS
dc.subjectCANCER
dc.subjectCHROMOSOME-11
dc.subjectLUNG
dc.subjectDNA
dc.subjectP53
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMolecular abnormalities associated with endocrine tumors of the uterine cervix
dc.typeartículo
dc.volumen72
sipa.codpersvinculados100278
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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