Clinical size is a poor predictor of invasion in melanoma of the lentigo maligna type

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dc.contributor.authorNavarrete-Dechent, Cristian
dc.contributor.authorAleissa, Saud
dc.contributor.authorConnolly, Karen
dc.contributor.authorHibler, Brian P.
dc.contributor.authorDusza, Stephen W.
dc.contributor.authorRossi, Anthony M.
dc.contributor.authorLee, Erica
dc.contributor.authorNehal, Kishwer S.
dc.date.accessioned2025-01-20T23:51:48Z
dc.date.available2025-01-20T23:51:48Z
dc.date.issued2021
dc.description.abstractBackground: There are no well-defined clinical factors to predict the risk of occult invasion in melanoma of the lentigo maligna type (LM) before complete histopathologic analysis.
dc.description.abstractObjective: To evaluate whether clinical size was a predictor of invasion in LM and subclinical extension.
dc.description.abstractMethods: Consecutive cases of LM were recorded in a prospectively maintained database from 2006 to 2019. Patient and tumor data were recorded during initial evaluation. The LM clinical area was calculated in square millimeters (length X width). All patients were treated with staged excision.
dc.description.abstractResults: We included 600 patients. The mean age was 65.9 years (standard deviation, 12.3; range, 27-95 years); 62.8% (n = 377) were men. The mean LM clinical area was 128.32 mm(2) for in situ lesions versus 200.14 mm for invasive lesions (P = .1). Based on quantile regression, the median margin required for complete removal increased with LM clinical area.
dc.description.abstractLimitations: The study was performed in a tertiary cancer center with possible referral bias and more complex cases.
dc.description.abstractConclusions: LM can present with variable clinical size, which may correlate with subclinical extension; however, the presence of invasion is not well estimated by LM clinical area.
dc.description.funderNational Cancer Institute/National Institutes of Health
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jaad.2020.10.023
dc.identifier.eissn1097-6787
dc.identifier.issn0190-9622
dc.identifier.urihttps://doi.org/10.1016/j.jaad.2020.10.023
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94857
dc.identifier.wosidWOS:000753253800027
dc.issue.numero5
dc.language.isoen
dc.pagina.final1301
dc.pagina.inicio1295
dc.revistaJournal of the american academy of dermatology
dc.rightsacceso restringido
dc.subjectBreslow
dc.subjectinvasion
dc.subjecthead and neck
dc.subjectlentigo maligna
dc.subjectlentigo maligna melanoma
dc.subjectmelanoma
dc.subjectprognosis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClinical size is a poor predictor of invasion in melanoma of the lentigo maligna type
dc.typeartículo
dc.volumen84
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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