Impact of Hypoxia over Human Viral Infections and Key Cellular Processes

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dc.catalogadorpau
dc.contributor.authorAntonia Reyes
dc.contributor.authorLuisa F. Duarte
dc.contributor.authorMónica A. Farías
dc.contributor.authorEduardo Tognarelli
dc.contributor.authorAlexis M. Kalergis
dc.contributor.authorBueno Ramirez, Susan Marcela
dc.contributor.authorPablo A. González
dc.date.accessioned2024-03-08T19:00:12Z
dc.date.available2024-03-08T19:00:12Z
dc.date.issued2021
dc.description.abstractOxygen is essential for aerobic cells, and thus its sensing is critical for the optimal maintenance of vital cellular and tissue processes such as metabolism, pH homeostasis, and angiogenesis, among others. Hypoxia-inducible factors (HIFs) play central roles in oxygen sensing. Under hypoxic conditions, the α subunit of HIFs is stabilized and forms active heterodimers that translocate to the nucleus and regulate the expression of important sets of genes. This process, in turn, will induce several physiological changes intended to adapt to these new and adverse conditions. Over the last decades, numerous studies have reported a close relationship between viral infections and hypoxia. Interestingly, this relation is somewhat bidirectional, with some viruses inducing a hypoxic response to promote their replication, while others inhibit hypoxic cellular responses. Here, we review and discuss the cellular responses to hypoxia and discuss how HIFs can promote a wide range of physiological and transcriptional changes in the cell that modulate numerous human viral infections.
dc.format.extent24 páginas
dc.fuente.origenORCID
dc.identifier.doi10.3390/ijms22157954
dc.identifier.urihttps://doi.org/10.3390/ijms22157954
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84316
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramirez, Susan Marcela; 0000-0002-7551-8088; 113541
dc.issue.numero15
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaInternational Journal of Molecular Sciences
dc.rightsacceso abierto
dc.titleImpact of Hypoxia over Human Viral Infections and Key Cellular Processes
dc.typeartículo
dc.volumen22
sipa.codpersvinculados113541
sipa.trazabilidadORCID;2024-01-15
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