PPAR alpha and PPAR gamma regulate the nucleoside transporter hENT1

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dc.contributor.authorMontero, Trinidad D.
dc.contributor.authorRacordon, Dusan
dc.contributor.authorBravo, Loreto
dc.contributor.authorOwen, Gareth I.
dc.contributor.authorBronfman, Miguel L.
dc.contributor.authorLeisewitz, Andrea V.
dc.date.accessioned2024-01-10T12:41:39Z
dc.date.available2024-01-10T12:41:39Z
dc.date.issued2012
dc.description.abstractHuman equilibrative nucleoside transporter 1 (hENT1) is an important determinant for nucleoside analog based chemotherapy success. Preliminary data suggest hENT1 regulation by PPARs. Using A2780 cells, we investigated the role of PPARs on hENT1 expression and activity.
dc.description.abstractPPAR alpha and PPAR gamma agonists, Wy14,643 and RGZ, increased hENT1 expression, but only PPAR alpha activation or overexpression resulted in higher hENT1 transport activity. On the other hand, promoter analysis showed two putative PPRE in hENT1 promoter and luciferase-coupled promoter constructs were generated and analyzed. Our results suggest that PPAR alpha-but not PPAR gamma-mediated expression regulation of hENT1 is PPRE-dependent. In conclusion, PPAR alpha and PPAR gamma activation modulate hENT1 expression. (C) 2012 Elsevier Inc. All rights reserved.
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital20-03-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.bbrc.2012.02.035
dc.identifier.issn0006-291X
dc.identifier.pubmedidMEDLINE:22349506
dc.identifier.urihttps://doi.org/10.1016/j.bbrc.2012.02.035
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77437
dc.identifier.wosidWOS:000301911000047
dc.information.autorucMedicina;Bravo L ;S/I;1010710
dc.information.autorucCiencias Biológicas;Bronfman M;S/I;98819
dc.information.autorucMedicina;Leisewitz A;S/I;94860
dc.information.autorucCiencias Biológicas;Montero T;S/I;149727
dc.information.autorucCiencias Biológicas;Owen G;S/I;1000459
dc.information.autorucCiencias Biológicas;Racordon D ;S/I;156068
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final411
dc.pagina.inicio405
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.revistaBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
dc.rightsacceso restringido
dc.subjectEquilibrative nucleoside transporter
dc.subjectPPAR alpha
dc.subjectChemotherapeutic drugs
dc.subjectPROLIFERATOR-ACTIVATED RECEPTORS
dc.subjectLIPID-METABOLISM
dc.subjectIN-VIVO
dc.subjectCANCER
dc.subjectGEMCITABINE
dc.subjectMECHANISMS
dc.subjectCELLS
dc.subjectTHIAZOLIDINEDIONES
dc.subjectDIFFERENTIATION
dc.subjectSENSITIVITY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePPAR alpha and PPAR gamma regulate the nucleoside transporter hENT1
dc.typeartículo
dc.volumen419
sipa.codpersvinculados1010710
sipa.codpersvinculados98819
sipa.codpersvinculados94860
sipa.codpersvinculados149727
sipa.codpersvinculados1000459
sipa.codpersvinculados156068
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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