Proteinuria in Hantavirus Cardiopulmonary Syndrome: A Frequent Finding Linked To Mortality

dc.contributor.authorLopez, Rene
dc.contributor.authorEspinoza, Mauricio
dc.contributor.authorGraf, Jeronimo
dc.contributor.authorMertz, Gregory
dc.contributor.authorFerres, Marcela
dc.contributor.authorCalvo, Mario
dc.contributor.authorVial, Cecilia
dc.contributor.authorVial, Pablo A.
dc.date.accessioned2025-01-20T22:06:41Z
dc.date.available2025-01-20T22:06:41Z
dc.date.issued2021
dc.description.abstractObjectives: To determine the relative frequency and prognosis value of proteinuria in hantavirus cardiopulmonary syndrome (HCPS) due to Andes virus. Methods: This observational analytical study prospectively obtained data from patients admitted to 12 health centers in nine Chilean cities between 2001 and 2018. Only patients with confirmed Andes virus HCPS and laboratory characterization that included qualitative proteinuria determination at admission were considered. Results: The database involved 175 patients, 95 of them had a measurement of urine protein at the time of hospital admission. They were mainly male (71%) and the median age was 35 [22-47] years. Median duration of the febrile prodromal time was 5 [4-7] days. Hospital length of stay and hospital mortality rate were 10 [7-14] days and 21.1%, respectively. Seventy-three patients (77%) were identified with proteinuria at admission, which was associated with increased mortality rate (26% versus 5%, p = 0.036) and the relative risk was 1.3 [1.1-1.6], p = 0.002. Conclusions: Proteinuria is a frequent finding in patients with HCPS, which is associated with a higher mortality rate. (c) 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ijid.2021.07.026
dc.identifier.eissn1878-3511
dc.identifier.issn1201-9712
dc.identifier.urihttps://doi.org/10.1016/j.ijid.2021.07.026
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94219
dc.identifier.wosidWOS:000705820500023
dc.language.isoen
dc.pagina.final468
dc.pagina.inicio466
dc.revistaInternational journal of infectious diseases
dc.rightsacceso restringido
dc.subjectHantavirus cardiopulmonary syndrome
dc.subjectAndes virus
dc.subjectProteinuria
dc.subjectMortality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleProteinuria in Hantavirus Cardiopulmonary Syndrome: A Frequent Finding Linked To Mortality
dc.typeartículo
dc.volumen110
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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