Liver resection for hepatolithiasis: A multicenter experience in Latin America

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dc.contributor.authorGarcia, Daniel
dc.contributor.authorMarino, Carlo
dc.contributor.authorCoelho, Fabricio Ferreira
dc.contributor.authorRebolledo, Patricia
dc.contributor.authorAchurra, Pablo
dc.contributor.authorFonseca, Gilton Marques
dc.contributor.authorKruger, Jaime A. P.
dc.contributor.authorVinuela, Eduardo
dc.contributor.authorBriceno, Eduardo
dc.contributor.authorD'Albuquerque, Luiz Carneiro
dc.contributor.authorJarufe, Nicolas
dc.contributor.authorMartinez, Jorge A.
dc.contributor.authorHerman, Paulo
dc.contributor.authorDib, Martin J.
dc.date.accessioned2025-01-20T20:17:52Z
dc.date.available2025-01-20T20:17:52Z
dc.date.issued2023
dc.description.abstractBackground: Hepatolithiasis is a prevalent disease in Asia but rare in Western countries. An increasing number of cases have been reported in Latin America. Liver resection has been proposed as a definitive treatment for complete stone clearance. The aim of this study was to evaluate the postoperative out-comes of liver resection for the treatment of hepatolithiasis in 2 large hepatobiliary reference centers from South America.Methods: We conducted a retrospective descriptive analysis from patients with hepatolithiasis who underwent liver resection between November 1986 and December 2018, in 2 Latin-American centers in Chile and Brazil.Results: One hundred forty-nine patients underwent liver resection for hepatolithiasis (72 in Chile, 77 in Brazil). The mean age was 49 years and most patients were female (62.4%). Hepatolithiasis was localized in the left lobe (61.7%), right lobe (24.2%), and bilateral lobe (14.1%). Bilateral lithiasis was associated with higher incidence of preoperative and postoperative cholangitis (81% vs 46.9% and 28.6% vs 6.1%) and need for hepaticojejunostomy (52.4%). In total, 38.9% of patients underwent major hepatectomy and 14.1% were laparoscopic. The postoperative stone clearance was 100%. The 30-day morbidity and mortality rates were 30.9% and 0.7%, respectively. Cholangiocarcinoma was seen in 2 specimens, and no post-operative malignancy were seen after a median follow-up of 38 months. Fourteen patients (9.4%) had intrahepatic stones recurrence.Conclusions: Liver resection is an effective and definitive treatment for patients with hepatolithiasis. Bilateral hepatolithiasis was associated with perioperative cholangitis, the need for hepaticojejunostomy, and recurrent disease. Resection presents a high rate of biliary tree stone clearance and excellent long-term results, with low recurrence rates and low risk of malignancy.(c) 2022 Elsevier Inc. All rights reserved.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.surg.2022.10.024
dc.identifier.issn0039-6060
dc.identifier.urihttps://doi.org/10.1016/j.surg.2022.10.024
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92426
dc.identifier.wosidWOS:000927281300001
dc.issue.numero2
dc.language.isoen
dc.pagina.final304
dc.pagina.inicio299
dc.revistaSurgery
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLiver resection for hepatolithiasis: A multicenter experience in Latin America
dc.typeartículo
dc.volumen173
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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