Studies on quinones. Part 42: Synthesis of furylquinone and hydroquinones with antiproliferative activity against human tumor cell lines

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dc.contributor.authorBenites, Julio
dc.contributor.authorValderrama, Jaime A.
dc.contributor.authorRivera, Felipe
dc.contributor.authorRojo, Leonel
dc.contributor.authorCampos, Nair
dc.contributor.authorPedro, Madalena
dc.contributor.authorJose Nascimento, Maria Saeo
dc.date.accessioned2024-01-10T13:43:39Z
dc.date.available2024-01-10T13:43:39Z
dc.date.issued2008
dc.description.abstractThe preparation of furyl-1,4-quinone and hydroquinones by reaction of 2-furaldehyde N,N-dimethylhydrazone with benzo- and naphthoquinones is reported. Access to furylnaphthoquinones from unactivated quinones requires acid-induced conditions, however oxidative coupling reactions of activated quinones proceed under neutral conditions. The in vitro cytotoxic activity of the prepared compounds against a panel of three human cancer cell lines has been studied. Most of the furyl-1,4-quinones exhibited good antiproliferative activity (GI(50) = 6.5-33.5 mu m) against the MCF-7, NCI-H460, and SF-268 (CNS cancer) cell lines chosen for testing. (C) 2007 Elsevier Ltd. All rights reserved.
dc.fechaingreso.objetodigital21-03-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.bmc.2007.10.028
dc.identifier.eissn1464-3391
dc.identifier.issn0968-0896
dc.identifier.pubmedidMEDLINE:17964791
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2007.10.028
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78715
dc.identifier.wosidWOS:000253581500026
dc.information.autorucQuímica;Valderrama J;S/I;98772
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final868
dc.pagina.inicio862
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.revistaBIOORGANIC & MEDICINAL CHEMISTRY
dc.rightsacceso restringido
dc.subjectquinones
dc.subjectMichael addition
dc.subjectoxidative coupling
dc.subjectcytotoxicity
dc.subjectLEISHMANICIDAL ACTIVITY
dc.subjectCYTOTOXICITY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleStudies on quinones. Part 42: Synthesis of furylquinone and hydroquinones with antiproliferative activity against human tumor cell lines
dc.typeartículo
dc.volumen16
sipa.codpersvinculados98772
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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