EFFECT OF A CALCIUM INHIBITOR, NIFEDIPINE, ON EXERCISE TOLERANCE IN PATIENTS WITH ANGINA-PECTORIS - A DOUBLE-BLIND-STUDY

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dc.contributor.authorCORBALAN, R
dc.contributor.authorGONZALEZ, R
dc.contributor.authorCHAMORRO, G
dc.contributor.authorMUNOZ, M
dc.contributor.authorRODRIGUEZ, JA
dc.contributor.authorCASANEGRA, P
dc.date.accessioned2025-01-23T19:44:11Z
dc.date.available2025-01-23T19:44:11Z
dc.date.issued1981
dc.description.abstractThe effect of nifedipine on exercise tolerance was studied in 30 patients with stable angina and positive graded exercise testing. Treadmill exercise testing was performed on each of 5 consecutive days. Placebo or nifedipine, 10 mg sublingually, was given 30 min before exercise on the 3rd day. The following day the intervention was reversed in a double-blind manner. Angina was abolished by nifedipine but not by placebo in 12 patients (40%). The time to onset of angina in the remaining patients increased from 4.1 .+-. 0.4 (SEM [standard error of mean]) to 6.7 .+-. 0.6 min (P < 0.001). Time to ST depression .gtoreq. 2 mm increased from 4.0 .+-. 0.3 to 5.4 .+-. 0.5 min, while duration of exercise increased from 6.3 .+-. 0.3 to 8.2 .+-. 0.4 min (P < 0.001). The maximum heart rate was 145 .+-. 3.3 with nifedipine and 122 .+-. 3.8 min-1 with placebo (P < 0.01). Resting systolic blood pressure decreased 30 min after nifedipine administration from 131 .+-. 3.4 to 106 .+-. 2.9 mm Hg (P < 0.01). Maximal systolic blood pressure during exercise was lower with nifedipine (127 .+-. 4.8 mm Hg) than with placebo (155 .+-. 8.6 mm Hg, P < 0.01). Nifedipine significantly improves the exercise tolerance of patients with stable angina pectoris by decreasing peripheral vascular resistance and myocardial O2 demand.
dc.fuente.origenWOS
dc.identifier.eissn1931-3543
dc.identifier.issn0012-3692
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99972
dc.identifier.wosidWOS:A1981LE47400012
dc.issue.numero3
dc.language.isoen
dc.pagina.final305
dc.pagina.inicio302
dc.revistaChest
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEFFECT OF A CALCIUM INHIBITOR, NIFEDIPINE, ON EXERCISE TOLERANCE IN PATIENTS WITH ANGINA-PECTORIS - A DOUBLE-BLIND-STUDY
dc.typeartículo
dc.volumen79
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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