Increased number of circulating endothelial cells and plasma markers of endothelial damage in chronic cocaine users

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dc.contributor.authorSaez, Claudia G.
dc.contributor.authorOlivares, Paulina
dc.contributor.authorPallavicini, Julio
dc.contributor.authorPanes, Olga
dc.contributor.authorMoreno, Natalia
dc.contributor.authorMassardo, Teresa
dc.contributor.authorMezzano, Diego
dc.contributor.authorPereira, Jaime
dc.date.accessioned2024-01-10T13:49:23Z
dc.date.available2024-01-10T13:49:23Z
dc.date.issued2011
dc.description.abstractBackground: Cocaine use has been related with the development of accelerated atherosclerosis and with an increased risk of cardiac and cerebrovascular events, such as myocardial infarction, sudden cardiac death, and ischemic stroke. The underlying mechanisms leading to these complications are not fully understood, although thrombus formation and altered vascular function are prominent findings.
dc.description.abstractObjectives: Our aim was to evaluate markers of endothelial dysfunction in chronic cocaine consumers before and after drug withdrawal. Patients/Methods: We determined circulating endothelial cells (CECs) and plasma levels of stromal cell-derived factor-1 (SDF-1), monocyte chemotactic protein-1(MCP-1), soluble intracellular adhesion molecule (sICAM), high-sensitivity C reactive protein (hsCRP) and endothelin-1(ET-1), in DSM-IV cocaine addicts at baseline and after one month of cocaine abstinence.
dc.description.abstractResults: Cocaine users showed a strikingly higher numbers of CEC (62.35 +/- 18.4 vs 8.25 +/- 13.8 CEC/mL) and significantly elevated plasma levels for all the markers evaluated as compared to the control group. After cocaine withdrawal, patients improved SDF-1, ET-1, hsCRP and sICAM levels. However, CEC number and MCP1 plasma levels remained significantly elevated. All the results were adjusted for blood levels of cholesterol and triglycerides and for smoking habit.
dc.description.abstractConclusions: Our results demonstrated that chronic cocaine consumption alters several functions of the endothelium towards a pro-thrombotic condition and that some of those functions remain abnormal even after short-term drug withdrawal. These observations support the notion that endothelial dysfunction may play a key role in the pathogenesis of ischemic vascular disease observed in cocaine abusers. (C) 2011 Elsevier Ltd. All rights reserved.
dc.description.funderFONDECYT (Fondo de Desarrollo Cientifico y Tecnologico, Ministry of Education of Chile)
dc.fechaingreso.objetodigital11-04-2024
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.thromres.2011.04.019
dc.identifier.issn0049-3848
dc.identifier.pubmedidMEDLINE:21601240
dc.identifier.urihttps://doi.org/10.1016/j.thromres.2011.04.019
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79446
dc.identifier.wosidWOS:000295212200004
dc.information.autorucMedicina;Mezzano D ;S/I;99455
dc.information.autorucMedicina;Moreno N ;S/I;163722
dc.information.autorucMedicina;Olivares P ;S/I;1007475
dc.information.autorucMedicina;Pallavicini J ;S/I;98396
dc.information.autorucMedicina;Panes O ;S/I;90271
dc.information.autorucMedicina;Pereira J;S/I;99371
dc.information.autorucMedicina;Saez C ;S/I;102375
dc.issue.numero4
dc.language.isoen
dc.nota.accesoContenido parcial
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.revistaTHROMBOSIS RESEARCH
dc.rightsacceso restringido
dc.subjectCirculating endothelial cells
dc.subjectCocaine
dc.subjectEndothelial dysfunction
dc.subjectVascular damage
dc.subjectVON-WILLEBRAND-FACTOR
dc.subjectACUTE CORONARY SYNDROMES
dc.subjectCARDIOVASCULAR COMPLICATIONS
dc.subjectVASCULAR-DISEASE
dc.subjectDYSFUNCTION
dc.subjectATHEROSCLEROSIS
dc.subjectEXPRESSION
dc.subjectBIOMARKERS
dc.subjectAPOPTOSIS
dc.subjectPROTEIN
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIncreased number of circulating endothelial cells and plasma markers of endothelial damage in chronic cocaine users
dc.typeartículo
dc.volumen128
sipa.codpersvinculados99455
sipa.codpersvinculados163722
sipa.codpersvinculados1007475
sipa.codpersvinculados98396
sipa.codpersvinculados90271
sipa.codpersvinculados99371
sipa.codpersvinculados102375
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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