Circumscribed palmar hypokeratosis: clinical evolution and ultrastructural study after prolonged treatment with topical calcipotriol

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dc.contributor.authorUrbina, F
dc.contributor.authorMisad, C
dc.contributor.authorGonzalez, S
dc.date.accessioned2024-01-10T13:11:46Z
dc.date.available2024-01-10T13:11:46Z
dc.date.issued2005
dc.description.abstractCircumscribed palmar hypokeratosis is a recently described condition that consists of a solitary area of depressed skin affecting the palm (or sole). Its histo pathological features include a thinned horny layer, a slightly diminished granular cell layer, and intraepidermal vacuolated cells. Prolonged treatment with topical calcipotriol resulted in complete recovery of the affected zone in the case reported here. A second biopsy of the lesion taken at around the fourth year of therapy showed a normalization of the granular layer, a reduction in the intraepidermal vacuolated cells, and a somewhat thicker horny layer. An ultrastructural study carried out at the same time showed a reduction in keratin bundles and keratohyalin granules, and an increase in lipid droplets up to the horny layer. These findings and the therapeutic response to topical calcipotriol support the concept that circumscribed palmar hypokeratosis is a focalized abnormal keratinization defect morphologically expressed at the granular and horny layers.
dc.fechaingreso.objetodigital2024-05-09
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1468-3083.2005.01197.x
dc.identifier.issn0926-9959
dc.identifier.pubmedidMEDLINE:15987302
dc.identifier.urihttps://doi.org/10.1111/j.1468-3083.2005.01197.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78092
dc.identifier.wosidWOS:000230729400021
dc.information.autorucMedicina;González S;S/I;99856
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final494
dc.pagina.inicio491
dc.publisherBLACKWELL PUBLISHING
dc.revistaJOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
dc.rightsacceso restringido
dc.subjectcalcipotriol
dc.subjecthypokeratosis
dc.subjectkeratin
dc.subjectkeratinization defect
dc.subjectPSORIASIS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCircumscribed palmar hypokeratosis: clinical evolution and ultrastructural study after prolonged treatment with topical calcipotriol
dc.typeartículo
dc.volumen19
sipa.codpersvinculados99856
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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