Photoaged polystyrene nanoplastics exposure results in reproductive toxicity due to oxidative damage in Caenorhabditis elegans

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dc.contributor.authorLeon, Rocio Errazuriz
dc.contributor.authorSalcedo, Vicente Andre Araya
dc.contributor.authorMiguel, Francisco Javier Novoa San
dc.contributor.authorTardio, Cynthia Rosa Andrea Llanquinao
dc.contributor.authorBriceno, Adolfo Andres Tobar
dc.contributor.authorFouilloux, Stefano Francesco Cherubini
dc.contributor.authorBarbosa, Marcela de Matos
dc.contributor.authorBarros, Cesar Antonio Saldias
dc.contributor.authorWaldman, Walter Ruggeri
dc.contributor.authorEspinosa-Bustos, Christian
dc.contributor.authorCarneiro, Maria Fernanda Hornos
dc.date.accessioned2025-01-20T16:18:33Z
dc.date.available2025-01-20T16:18:33Z
dc.date.issued2024
dc.description.abstractThe increase of plastic production together with the incipient reuse/recycling system has resulted in massive discards into the environment. This has facilitated the formation of micro- and nanoplastics (MNPs) which poses major risk for environmental health. Although some studies have investigated the effects of pristine MNPs on reproductive health, the effects of weathered MNPs have been poorly investigated. Here we show in Caenorhabditis elegans that exposure to photoaged polystyrene nanoplastics (PSNP-UV) results in worse reproductive performance than pristine PSNP (i.e., embryonic/larval lethality plus a decrease in the brood size, accompanied by a high number of unfertilized eggs), besides it affects size and locomotion behavior. Those effects were potentially generated by reactive products formed during UV -irradiation, since we found higher levels of reactive oxygen species and increased expression of GST-4 in worms exposed to PSNP-UV. Those results are supported by physical -chemical characterization analyses which indicate significant formation of oxidative degradation products from PSNP under UV -C irradiation. Our study also demonstrates that PSNP accumulate predominantly in the gastrointestinal tract of C. elegans (with no accumulation in the gonads), being completely eliminated at 96 h post -exposure. We complemented the toxicological analysis of PSNP/PSNP-UV by showing that the activation of the stress response via DAF-16 is dependent of the nanoplastics accumulation. Our data suggest that exposure to the wild PSNP, i.e., polystyrene nanoplastics more similar to those actually found in the environment, results in more important reprotoxic effects. This is associated with the presence of degradation products formed during UV -C irradiation and their interaction with biological targets.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.envpol.2024.123816
dc.identifier.eissn1873-6424
dc.identifier.issn0269-7491
dc.identifier.urihttps://doi.org/10.1016/j.envpol.2024.123816
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90652
dc.identifier.wosidWOS:001223293300001
dc.language.isoen
dc.revistaEnvironmental pollution
dc.rightsacceso restringido
dc.subjectC. elegans
dc.subjectReprotoxicity
dc.subjectPhotoaged polystyrene nanoplastics
dc.subjectToxicokinetics
dc.subjectEndocrine disruptor chemicals
dc.subject.ods12 Responsible Consumption and Production
dc.subject.ods11 Sustainable Cities and Communities
dc.subject.ods14 Life Below Water
dc.subject.ods06 Clean Water and Sanitation
dc.subject.odspa12 Producción y consumo responsable
dc.subject.odspa11 Ciudades y comunidades sostenibles
dc.subject.odspa14 Vida submarina
dc.subject.odspa06 Agua limpia y saneamiento
dc.titlePhotoaged polystyrene nanoplastics exposure results in reproductive toxicity due to oxidative damage in Caenorhabditis elegans
dc.typeartículo
dc.volumen348
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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