Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes
dc.contributor.author | Galaz, Jose | |
dc.contributor.author | Romero, Roberto | |
dc.contributor.author | Slutsky, Rebecca | |
dc.contributor.author | Xu, Yi | |
dc.contributor.author | Motomura, Kenichiro | |
dc.contributor.author | Para, Robert | |
dc.contributor.author | Pacora, Percy | |
dc.contributor.author | Panaitescu, Bogdan | |
dc.contributor.author | Hsu, Chaur Dong | |
dc.contributor.author | Kacerovsky, Marian | |
dc.contributor.author | Gomez Lopez, Nardhy | |
dc.date.accessioned | 2024-01-10T13:11:36Z | |
dc.date.available | 2024-01-10T13:11:36Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Background: Preterm birth is the leading cause of perinatal morbidity and mortality. Preterm prelabor rupture of membranes (pPROM) occurs in 30% of preterm births; thus, this complication is a major contributor to maternal and neonatal morbidity. However, the cellular immune responses in amniotic fluid of women with pPROM have not been investigated. | |
dc.description.abstract | Methods: Amniotic fluid samples were obtained from women with pPROM and a positive (n = 7) or negative (n =10) microbiological culture. Flow cytometry was performed to evaluate the phenotype and number of amniotic fluid leukocytes. The correlation between amniotic fluid immune cells and an interleukin-6 (IL-6) concentration or a white blood cell (WBC) count in amniotic fluid was calculated. | |
dc.description.abstract | Results: Women with pPROM and a positive amniotic fluid culture had (1) a greater number of total leukocytes in amniotic fluid, including neutrophils and monocytes/macrophages and (2) an increased number of total T cells in amniotic fluid, namely CD4+ T cells and CD8+ T cells, but not B cells. The numbers of neutrophils and monocytes/macrophages were positively correlated with IL -6 concentrations and WBC counts in amniotic fluid of women with pPROM. | |
dc.description.abstract | Conclusion: Women with pPROM and a positive amniotic fluid culture exhibit a more severe cellular immune response than those with a negative culture, which is associated with well-known markers of intra-amniotic inflammation. | |
dc.description.funder | Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and | |
dc.description.funder | NICHD/NIH/DHHS | |
dc.description.funder | Wayne State University Perinatal Initiative in Maternal, Perinatal and Child Health | |
dc.format.extent | 12 páginas | |
dc.fuente.origen | WOS | |
dc.identifier.doi | 10.1515/jpm-2019-0395 | |
dc.identifier.eissn | 1619-3997 | |
dc.identifier.issn | 0300-5577 | |
dc.identifier.pubmedid | MEDLINE:32083453 | |
dc.identifier.uri | https://doi.org/10.1515/jpm-2019-0395 | |
dc.identifier.uri | https://repositorio.uc.cl/handle/11534/78070 | |
dc.identifier.wosid | WOS:000518390600005 | |
dc.information.autoruc | Ingeniería;Galaz Mora Jose Daniel;S/I;177842 | |
dc.issue.numero | 3 | |
dc.language.iso | en | |
dc.nota.acceso | Sin adjunto | |
dc.pagina.final | 233 | |
dc.pagina.inicio | 222 | |
dc.publisher | WALTER DE GRUYTER GMBH | |
dc.revista | JOURNAL OF PERINATAL MEDICINE | |
dc.rights | registro bibliográfico | |
dc.subject | acute chorioamnionitis | |
dc.subject | clinical chorioamnionitis | |
dc.subject | fetal inflammatory response | |
dc.subject | funisitis | |
dc.subject | innate immune cells | |
dc.subject | interleukin-6 | |
dc.subject | labor | |
dc.subject | microbial invasion of the amniotic cavity | |
dc.subject | pregnancy | |
dc.subject | prematurity | |
dc.subject | preterm labor | |
dc.subject | MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA | |
dc.subject | ACTIVATING PEPTIDE-1 INTERLEUKIN-8 | |
dc.subject | TUMOR-NECROSIS-FACTOR | |
dc.subject | PREMATURE RUPTURE | |
dc.subject | FETAL MEMBRANES | |
dc.subject | INTRAAMNIOTIC INFLAMMATION | |
dc.subject | MICROBIAL INVASION | |
dc.subject | INTRAUTERINE INFECTION | |
dc.subject | HUMAN PARTURITION | |
dc.subject | GRAM STAIN | |
dc.subject.ods | 03 Good Health and Well-being | |
dc.subject.ods | 05 Gender Equality | |
dc.subject.odspa | 03 Salud y bienestar | |
dc.subject.odspa | 05 Igualdad de género | |
dc.title | Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes | |
dc.type | artículo | |
dc.volumen | 48 | |
sipa.codpersvinculados | 177842 | |
sipa.index | WOS | |
sipa.index | Scopus | |
sipa.trazabilidad | Carga SIPA;09-01-2024 |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes.pdf
- Size:
- 2.99 KB
- Format:
- Adobe Portable Document Format
- Description: