The long-term reinfection rate and the course of duodenal ulcer disease after eradication of <i>Helicobacter pylori</i> in a developing country

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dc.contributor.authorRollan, A
dc.contributor.authorGiancaspero, R
dc.contributor.authorFuster, F
dc.contributor.authorAcevedo, C
dc.contributor.authorFigueroa, C
dc.contributor.authorHola, K
dc.contributor.authorSchulz, M
dc.contributor.authorDuarte, I
dc.date.accessioned2025-01-21T01:31:42Z
dc.date.available2025-01-21T01:31:42Z
dc.date.issued2000
dc.description.abstractOBJECTIVE: The aim of this study was to evaluate the effect of Helicobacter pylori (H. pylori) eradication on the natural history of duodenal ulcer disease and the reinfection rate after treatment in a developing country.
dc.description.abstractMETHODS: A total of 111 H. pylori-infected patients with duodenal ulcer were treated with either omeprazole or famotidine plus two antibiotics for 2 wk. Those failed to respond to treatment were retreated with bismuth-based triple therapy.
dc.description.abstractRESULTS: The radication rate was 76% (95% CI: 67-83%). Eventually, H. pylori was eradicated in 96 of the 111 patients (86%), who were followed-up clinically and endoscopically for a mean of 37.2 months. The cumulative reinfection rate after eradication (Kaplan-Meier) was 8% +/- 3% in yr 1, 11% +/- 4% in yr 2, and 13% +/- 4% in yr 3. Nine of the 12 reinfections occurred during yr 1. Recurrence of duodenal ulcer was detected in five patients (5.2%), all of them during yr 1 of follow-up. Histologically, gastritis scores (according to the Sydney system) improved significantly after eradication.
dc.description.abstractCONCLUSIONS: In a high prevalence setting, H. pylori eradication and early reinfection rates after treatment are similar to rates observed in a low prevalence environment, whereas the late reinfection rate seems to be higher. However, up to 3 yr after treatment, most treated patients are free of H. pylori infection and/or ulcer activity. Even longer follow-up studies are necessary to determine whether specific retreatment policies are necessary to maintain long term eradication in developing countries.
dc.fuente.origenWOS
dc.identifier.eissn1572-0241
dc.identifier.issn0002-9270
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97124
dc.identifier.wosidWOS:000084690800010
dc.issue.numero1
dc.language.isoen
dc.pagina.final56
dc.pagina.inicio50
dc.revistaAmerican journal of gastroenterology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe long-term reinfection rate and the course of duodenal ulcer disease after eradication of <i>Helicobacter pylori</i> in a developing country
dc.typeartículo
dc.volumen95
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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