Biomarkers as predictors of renal damage in neonates undergoing cardiac surgery

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dc.contributor.authorBorchert, Evelyn
dc.contributor.authorde la Fuente, Rene
dc.contributor.authorGuzman, Ana Maria
dc.contributor.authorGonzalez, Katia
dc.contributor.authorRolle, Augusto
dc.contributor.authorMorales, Karina
dc.contributor.authorGonzalez, Rodrigo
dc.contributor.authorJalil, Roberto
dc.contributor.authorLema, Guillermo
dc.date.accessioned2024-01-10T12:11:07Z
dc.date.available2024-01-10T12:11:07Z
dc.date.issued2020
dc.description.abstractBackground:
dc.description.abstractAcute Kidney Injury is a complication in children with heart disease undergoing cardiac surgery with cardiopulmonary bypass. The aim of this study is to describe the behavior of KIM-1 (Kidney Injury Molecule) and NGAL (Neutrophil Gelatinase Associated Lipocalin) as early predictors of renal damage, comparing them with serum creatinine and creatinine clearance, in neonates undergoing cardiac surgery.
dc.description.abstractMethods:
dc.description.abstractTwenty-one (21) neonates, under 4 kg, with complex congenital heart diseases, RACHS-1 > 3, without preoperative renal failure, were studied. Serum creatinine and creatinine clearance were measured preoperatively and at 24, 48, 72, 96 hours postoperatively. Urinary samples of KIM-1(pg/ml) and NGAL (ng/ml) were collected after induction of anesthesia at 24 and 48 hours post-operatively.
dc.description.abstractResults:
dc.description.abstractnRIFLE criteria were used to divide cohorts in "NO AKI" (12 patients) and "AKI" (nine patients). In the AKI group, serum creatinine increased significantly and creatinine clearance decreased significantly at 24, 48, and 72 hours compared with their respective baseline values. There was no difference in KIM-1 and NGAL values between patients who developed AKI and those who did not at any measured time.
dc.description.abstractConclusions:
dc.description.abstractThe deterioration of renal function continues to be one of the most frequent complications in this population. In our study, biomarkers did not show any correlation with the appearance of AKI. It remains to be seen whether this behavior of the biomarkers is linked with the non-consistent release of these types of molecules in immature kidneys. It is likely that a larger panel of biomarkers together with other glomerular filtration rate assessment methods will provide more information about AKI diagnosis.
dc.fechaingreso.objetodigital2024-05-20
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1177/0267659120968377
dc.identifier.eissn1477-111X
dc.identifier.issn0267-6591
dc.identifier.pubmedidMEDLINE:33140691
dc.identifier.urihttps://doi.org/10.1177/0267659120968377
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76632
dc.identifier.wosidWOS:000627921600001
dc.information.autorucFacultad de Medicina; De La Fuente Sanhueza, Rene Francisco; S/I; 102089
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherSAGE PUBLICATIONS LTD
dc.revistaPERFUSION-UK
dc.rightsacceso restringido
dc.subjectAKI
dc.subjectbiomarkers
dc.subjectcongenital heart surgery
dc.subjectneonates
dc.subjectCPB
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBiomarkers as predictors of renal damage in neonates undergoing cardiac surgery
dc.typeartículo
sipa.codpersvinculados102089
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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