Comparison Between Dynamic Models for Predicting Response to Corticosteroids in Alcohol-Associated Hepatitis: A Global Cohort Study

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dc.catalogadorjwg
dc.contributor.authorIdalsoaga Ferrer, Francisco Javier
dc.contributor.authorDíaz Piga, Luis Antonio
dc.contributor.authorGuizzetti, Leonardo
dc.contributor.authorDunn, Winston
dc.contributor.authorMehta, Heer
dc.contributor.authorArnold, Jorge
dc.contributor.authorAyares Campos, Gustavo Ignacio
dc.contributor.authorMortuza, Rokhsana
dc.contributor.authorMahli, Gurpreet
dc.contributor.authorIslam, Alvi H.
dc.contributor.authorSarin, Shiv K.
dc.contributor.authorMaiwall, Rakhi
dc.contributor.authorZhang, Wei
dc.contributor.authorQian, Steve
dc.contributor.authorSimonetto, Douglas
dc.contributor.authorSingal, Ashwani K.
dc.contributor.authorElfeki, Mohamed A.
dc.contributor.authorRamirez-Cadiz, Carolina
dc.contributor.authorCabezas, Joaquin
dc.contributor.authorEchavarria, Victor
dc.contributor.authorCots, Meritxell Ventura
dc.contributor.authorLa Tijera, Maria Fatima Higuera-De
dc.contributor.authorAbraldes, Juan G.
dc.contributor.authorAl-Karaghouli, Mustafa
dc.contributor.authorJalal, Prasun K.
dc.contributor.authorAli Ibrahim, Mohamad
dc.contributor.authorGarcia-Tsao, Guadalupe
dc.contributor.authorGoyes, Daniela
dc.contributor.authorSkladany, Lubomir
dc.contributor.authorHavaj, Daniel J.
dc.contributor.authorSulejova, Karolina
dc.contributor.authorSelcanova, Svetlana Adamcova
dc.contributor.authorRincon, Diego
dc.contributor.authorShah, Vijay H.
dc.contributor.authorKamath, Patrick S.
dc.contributor.authorArrese, Marco
dc.contributor.authorBataller, Ramon
dc.contributor.authorArab, Juan Pablo
dc.date.accessioned2025-03-14T16:29:33Z
dc.date.available2025-03-14T16:29:33Z
dc.date.issued2025
dc.description.abstractSeveral dynamic models predict mortality and corticosteroid response in alcohol-associated hepatitis (AH), yet no consensus exists on the most effective model. This study aimed to assess predictive models for corticosteroid response and short-term mortality in severe AH within a global cohort. We conducted a multi-national study of patients with severe AH treated with corticosteroids for at least 7 days, enrolled between 2009 and 2019. Dynamic models-Lille-4, Lille-7, trajectory of serum bilirubin (TSB), and neutrophil-to-lymphocyte ratio (NLR)-were used to estimate 30- and 90-day mortality. Lille-7 demonstrated the highest accuracy for both 30- and 90-day mortality.
dc.description.funderChilean government through the Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT)
dc.fuente.origenORCID
dc.identifier.doi10.1111/apt.70024
dc.identifier.eissn1365-2036
dc.identifier.issn0269-2813
dc.identifier.urihttps://doi.org/10.1111/apt.70024
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102634
dc.identifier.wosidWOS:001424385300001
dc.information.autorucEscuela de Medicina; Idalsoaga Ferrer, Francisco Javier; S/I; 1017394
dc.information.autorucEscuela de Medicina; Díaz Piga, Luis Antonio; 0000-0002-8540-4930; 179253
dc.information.autorucEscuela de Medicina; Ayares Campos, Gustavo Ignacio; S/I; 1033904
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherWILEY
dc.revistaALIMENTARY PHARMACOLOGY & THERAPEUTICS
dc.rightsacceso restringido
dc.subjectalcohol
dc.subjectalcohol-associated liver disease
dc.subjectalcoholic cirrhosis
dc.subjectalcohol-related hepatitis
dc.subjectcirrhosis
dc.subjectend-stage liver disease
dc.subjectoutcome prediction
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleComparison Between Dynamic Models for Predicting Response to Corticosteroids in Alcohol-Associated Hepatitis: A Global Cohort Study
dc.typeartículo
sipa.codpersvinculados1017394
sipa.codpersvinculados179253
sipa.codpersvinculados1033904
sipa.trazabilidadORCID;2025-03-03
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