Effects of carvedilol on oxidative stress and chronotropic response to exercise in patients with chronic heart failure

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dc.contributor.authorCastro, P
dc.contributor.authorVukasovic, JL
dc.contributor.authorChiong, M
dc.contributor.authorDiaz Araya, G
dc.contributor.authorAlcaino, H
dc.contributor.authorCopaja, M
dc.contributor.authorValenzuela, R
dc.contributor.authorGreig, D
dc.contributor.authorPerez, O
dc.contributor.authorCorbalan, R
dc.contributor.authorLavandero, S
dc.date.accessioned2024-01-10T13:12:35Z
dc.date.available2024-01-10T13:12:35Z
dc.date.issued2005
dc.description.abstractBackground: Our previous studies suggest that the increase in heart rate from rest to peak exercise is reduced in patients with chronic heart failure (CHF) and this is associated with increased oxidative stress, as determined by malondialdehyde (MDA) plasma levels.
dc.description.abstractAim: To investigate the effects of carvedilol on the heart rate response to exercise and oxidative stress in patients with CHF.
dc.description.abstractMethods and results: Thirty stable NYHA classes II-III CHF patients received carvedilol therapy for 6 months, at a mean maintenance dose of 25 mg (range 6.25-50 mg/day). After treatment, the patients showed a significant improvement in their functional NYHA class (p=0.013), increased tell ventricular ejection fraction (LVEF) (24 +/- 1.4% to 31 +/- 2.3%, p=0.003) and 6-min walk distance (499 +/- 18 to 534 +/- 18 m, p=0.03), without changes in the peak VO2. At baseline, norepinephrine (NE) plasma levels increased with exercise (510 +/- 51 to 2513 +/- 230 pg/mL, p < 0.001), and these levels were not affected by carvedilol. Chronotropic responsiveness index (increase in heart rate divided by the increase in NE from rest to peak exercise) was not changed by carvedilol (0.049 +/- 0.001 to 0.042 +/- 0.001, p=0.6). MDA levels of CHF patients decreased after treatment with carvedilol (2.4 +/- 0.2 to 1.1 +/- 0.2 mu M p < 0.001), without changes in antioxidant enzyme activities.
dc.description.abstractConclusions: Carvedilol treatment in patients with CHF results in reduced oxidative stress Without restoration of the chronotropic responsiveness index. (c) 2004 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
dc.fechaingreso.objetodigital2024-04-16
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ejheart.2004.11.009
dc.identifier.eissn1879-0844
dc.identifier.issn1388-9842
dc.identifier.pubmedidMEDLINE:16227141
dc.identifier.urihttps://doi.org/10.1016/j.ejheart.2004.11.009
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78204
dc.identifier.wosidWOS:000234381000014
dc.information.autorucMedicina;Castro P;S/I;100212
dc.information.autorucMedicina;Corbalán R;S/I;98700
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final1039
dc.pagina.inicio1033
dc.publisherWILEY
dc.revistaEUROPEAN JOURNAL OF HEART FAILURE
dc.rightsacceso abierto
dc.subjectbeta-adrenergic antagonist
dc.subjectcarvedilol
dc.subjectoxidative stress
dc.subjectchronic heart failure
dc.subjectMETOPROLOL
dc.subjectANTIOXIDANT
dc.subjectMECHANISMS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEffects of carvedilol on oxidative stress and chronotropic response to exercise in patients with chronic heart failure
dc.typeartículo
dc.volumen7
sipa.codpersvinculados100212
sipa.codpersvinculados98700
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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