Episodic Binge-like Ethanol Reduces Skeletal Muscle Strength Associated with Atrophy, Fibrosis, and Inflammation in Young Rats

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dc.catalogadorjca
dc.contributor.authorCáceres-Ayala, Constanza
dc.contributor.authorMira, Rodrigo G.
dc.contributor.authorAcuña, María José
dc.contributor.authorBrandan, Enrique
dc.contributor.authorCerpa Nebott, Waldo
dc.contributor.authorRebolledo, Daniela L.
dc.date.accessioned2024-02-27T16:02:47Z
dc.date.available2024-02-27T16:02:47Z
dc.date.issued2023
dc.description.abstractBinge Drinking (BD) corresponds to episodes of ingestion of large amounts of ethanol in a short time, typically ≤2 h. BD occurs across all populations, but young and sports-related people are especially vulnerable. However, the short- and long-term effects of episodic BD on skeletal muscle function have been poorly explored. Young rats were randomized into two groups: control and episodic Binge-Like ethanol protocol (BEP) (ethanol 3 g/kg IP, 4 episodes of 2-days ON-2-days OFF paradigm). Muscle function was evaluated two weeks after the last BEP episode. We found that rats exposed to BEP presented decreased muscle strength and increased fatigability, compared with control animals. Furthermore, we observed that skeletal muscle from rats exposed to BEP presented muscle atrophy, evidenced by reduced fiber size and increased expression of atrophic genes. We also observed that BEP induced fibrotic and inflammation markers, accompanied by mislocalization of nNOSµ and high levels of protein nitration. Our findings suggest that episodic binge-like ethanol exposure alters contractile capacity and increases fatigue by mechanisms involving atrophy, fibrosis, and inflammation, which remain for at least two weeks after ethanol clearance. These pathological features are common to several neuromuscular diseases and might affect muscle performance and health in the long term.
dc.fechaingreso.objetodigital2024-06-05
dc.fuente.origenORCID
dc.identifier.doi10.3390/ijms24021655
dc.identifier.issn1422-0067
dc.identifier.urihttps://doi.org/10.3390/ijms24021655
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81341
dc.identifier.wosidWOS:000915518900001
dc.information.autorucFacultad de Ciencias Biológicas;Cáceres Ayala, Constanza Natalie;S/I;1027854
dc.information.autorucFacultad de Ciencias Biológicas;Acuña, María José; S/I;181470
dc.information.autorucFacultad de Ciencias Biológicas;Cerpa Nebott, Waldo;0000-0001-7344-0144;16584
dc.information.autorucFacultad de Ciencias Biológicas;Rebolledo López, Daniela Victoria;S/I;142327
dc.issue.numero1655
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final20
dc.pagina.inicio1
dc.revistaInternational Journal of Molecular Sciences
dc.rightsacceso abierto
dc.subjectBinge-drinking
dc.subjectAlcohol|Ethanol
dc.subjectEkeletal muscle
dc.subjectMuscle fatigue
dc.subjectFibrosis
dc.subjectAtrophy
dc.subjectCCN2/CTGF
dc.subjectAlcoholic myopathy
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEpisodic Binge-like Ethanol Reduces Skeletal Muscle Strength Associated with Atrophy, Fibrosis, and Inflammation in Young Rats
dc.typeartículo
dc.volumen24
sipa.codpersvinculados1027854
sipa.codpersvinculados181470
sipa.codpersvinculados16584
sipa.codpersvinculados142327
sipa.trazabilidadORCID;2024-01-15
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