Genotypic interaction between DRD4 and DAT1 loci is a high risk factor for attention-deficit/hyperactivity disorder in Chilean families

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dc.contributor.authorCarrasco, X
dc.contributor.authorRothhammer, P
dc.contributor.authorMoraga, M
dc.contributor.authorHenriquez, H
dc.contributor.authorChakraborty, R
dc.contributor.authorAboitiz, F
dc.contributor.authorRothhammer, F
dc.date.accessioned2024-01-10T12:39:13Z
dc.date.available2024-01-10T12:39:13Z
dc.date.issued2006
dc.description.abstractAttention-deficit/hyperactivity disorder, ADHD [MIM 126452], is a common, highly heritable neurobiological disorder of childhood onset, characterized by hyperactivity, impulsiveness, and/or inattentiveness. As part of an ongoing study of AMID, we carried out a family-based discordant sib-pair analysis to detect possible associations between dopamine receptor D4 (DRD4) and dopamine transporter 1 (DAT1) polymorphisms and ADHD in Chilean families. Both loci individually classified as homozygotes or heterozygotes for the DRD4 7-repeat and DAT1 10-repeat alleles, did not exhibit genotype frequency differences between affected children and their healthy siblings (Fisher's exact test P > 0.25 in both cases). However, the simultaneous presence of both DRD4 7-repeat heterozygosity and DAT1 10 allele homozygosity were significantly higher (34.6%) in cases (26), compared with their unaffected siblings (25) (4%; Fisher's exact test P = 0.0096; odds-ratio, OR = 12.71). Increased density of dopamine transporter in ADHD brains, along with abundance of 7-repeat D4 receptors in prefrontal cortex, which is impaired in ADHD patients, make the observed gene-gene interaction worthy of further incisive studies. (C) 2005 Wiley-Liss, Inc.
dc.fechaingreso.objetodigital03-04-2024
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/ajmg.b.30259
dc.identifier.eissn1552-485X
dc.identifier.issn1552-4841
dc.identifier.pubmedidMEDLINE:16342279
dc.identifier.urihttps://doi.org/10.1002/ajmg.b.30259
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77161
dc.identifier.wosidWOS:000234514400009
dc.information.autorucMedicina;Aboitiz F;S/I;100165
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final54
dc.pagina.inicio51
dc.publisherWILEY
dc.revistaAMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
dc.rightsacceso restringido
dc.subjectDRD4
dc.subjectDAT1
dc.subjectgenotypic interaction
dc.subjectADHD
dc.subjectassociation with (?)
dc.subjectDEFICIT HYPERACTIVITY DISORDER
dc.subjectDOPAMINE-D4 RECEPTOR GENE
dc.subjectDIAGNOSTIC-CRITERIA
dc.subjectTRANSPORTER GENE
dc.subjectTEACHER RATINGS
dc.subject7-REPEAT ALLELE
dc.subjectASSOCIATION
dc.subjectADHD
dc.subjectPOLYMORPHISM
dc.subjectPREVALENCE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGenotypic interaction between DRD4 and DAT1 loci is a high risk factor for attention-deficit/hyperactivity disorder in Chilean families
dc.typeartículo
dc.volumen141
sipa.codpersvinculados100165
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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