Comparison of Plasma Concentrations of Levobupivacaine With and Without Epinephrine for Transversus Abdominis Plane Block

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dc.catalogadorgrr
dc.contributor.authorCorvetto Aqueveque, Marcia Antonia
dc.contributor.authorEchevarria, Ghislaine C.
dc.contributor.authorFuente Lopez , Natalia Francisca de la
dc.contributor.authorMosqueira Podesta, Loreto Alejandra
dc.contributor.authorSolari Gajardo, Sandra
dc.contributor.authorAltermatt Couratier, Fernando René
dc.date.accessioned2024-08-20T21:22:11Z
dc.date.available2024-08-20T21:22:11Z
dc.date.issued2012
dc.description.abstract"Background and Objectives: The pharmacokinetics for levobupivacaine in transversus abdominis plane (TAP) blocks has not been previously reported. We aimed to determine the extent of the block and the effect on plasma concentrations of levobupivacaine with the addition of epinephrine.", "Methods: We enrolled 11 healthy volunteers in this double-blind, 2-intervention, 2-period crossover study. The intervention periods were defined as a unilateral left TAP block with 20 mL of 0.25% levobupivacaine with (E) or without (no E) 5 mu g/mL epinephrine. Subjects were randomized to E, followed by no E or no E followed by E, with 2-week washout period. Sensory dermatomal anesthesia was recorded. Blood samples were obtained for the measurement of plasma levobupivacaine levels.", "Results: The median cranial-to-caudal spread of sensory blockade for sharp touch was T9 (interquartile range [IQR], T7-T10) to L1 (IQR, T12-L1) with epinephrine and T9 (IQR, T8-T10) to T12 (IQR, T11-L1) without epinephrine (P > 0.05). The mean maximum arterial levobupivacaine concentrations with epinephrine were 0.36 (95% bootstrap confidence interval [95% CI], 0.30-0.42) mu g/mL and 0.63 (95% CI, 0.49-0.85) mu g/mL without epinephrine (P = 0.014, difference in means of 0.27 [95% CI, 0.12-0.46]). The mean maximal venous levobupivacaine concentration was 0.32 (95% CI, 0.28-0.39) mu g/mL and 0.49 (95% CI, 0.37-0.68) mu g/mL, with and without epinephrine, respectively (P = 0.006, difference in means of 0.17 [95% CI, 0.08-0.33]). The mean duration of the blockade was 10.2 hours (95% CI, 8.5-12.5 hours) with epinephrine and 10.3 hours (95% CI, 8.7-12.4 hours) without epinephrine (P = 1.000).", "Conclusions: Adding epinephrine to levobupivacaine reduces its peak plasma concentration after unilateral TAP blocks, with no remarkable effects on block characteristics or duration."]
dc.fuente.origenHistorial Académico
dc.fuente.origenORCID
dc.identifier.doi10.1097/AAP.0b013e31826c330a
dc.identifier.issn1098-7339
dc.identifier.pubmedid23038415
dc.identifier.scopusidSCOPUS_ID:2-s2.0-84868272697
dc.identifier.urihttps://doi.org/10.1097/AAP.0b013e31826c330a
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87562
dc.identifier.wosidWOS:000310431800013
dc.information.autorucEscuela de Medicina; Echevarria Eyarzun Ghislaine Carolina;S/I;152736
dc.information.autorucEscuela de Medicina; Altermatt Couratier, Fernando Rene; 0000-0002-0464-8643; 7381
dc.information.autorucEscuela de Medicina; Corvetto Aqueveque, Marcia Antonia; 0000-0003-4688-0210; 146036
dc.information.autorucEscuela de Medicina; Mosqueira Podesta, Loreto Alejandra; S/I; 190164
dc.information.autorucEscuela de Medicina; Solari Gajardo, Sandra; 0000-0002-3185-4717; 1871
dc.information.autorucEscuela de Medicina; De La Fuente Lopez , Natalia Francisca; S/I; 226699
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final637
dc.pagina.inicio633
dc.revistaRegional Anesthesia and Pain Medicine
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleComparison of Plasma Concentrations of Levobupivacaine With and Without Epinephrine for Transversus Abdominis Plane Block
dc.typeartículo
dc.volumen37
sipa.codpersvinculados152736
sipa.codpersvinculados7381
sipa.codpersvinculados146036
sipa.codpersvinculados190164
sipa.codpersvinculados1871
sipa.codpersvinculados226699
sipa.trazabilidadHistorial Académico;09-07-2021
sipa.trazabilidadORCID
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