Neural conditional ablation of the protein tyrosine phosphatase receptor Delta PTPRD impairs gliogenesis in the developing mouse brain cortex

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dc.article.number1357862
dc.article.number1357862
dc.catalogadoraba
dc.contributor.authorCornejo Castillo, Francisca Alejandra
dc.contributor.authorFranchini, Nayhara
dc.contributor.authorCortes, Bastián I.
dc.contributor.authorElgueta, Daniela
dc.contributor.authorCancino Lobos, Gonzalo Ignacio
dc.date.accessioned2024-04-24T21:16:16Z
dc.date.available2024-04-24T21:16:16Z
dc.date.issued2024
dc.description.abstractNeurodevelopmental disorders are characterized by alterations in the development of the cerebral cortex, including aberrant changes in the number and function of neural cells. Although neurogenesis is one of the most studied cellular processes in these pathologies, little evidence is known about glial development. Genetic association studies have identified several genes associated with neurodevelopmental disorders. Indeed, variations in the PTPRD gene have been associated with numerous brain disorders, including autism spectrum disorder, restless leg syndrome, and schizophrenia. We previously demonstrated that constitutive loss of PTPRD expression induces significant alterations in cortical neurogenesis, promoting an increase in intermediate progenitors and neurons in mice. However, its role in gliogenesis has not been evaluated. To assess this, we developed a conditional knockout mouse model lacking PTPRD expression in telencephalon cells. Here, we found that the lack of PTPRD in the mouse cortex reduces glial precursors, astrocytes, and oligodendrocytes. According to our results, this decrease in gliogenesis resulted from a reduced number of radial glia cells at gliogenesis onset and a lower gliogenic potential in cortical neural precursors due to less activation of the JAK/STAT pathway and reduced expression of gliogenic genes. Our study shows PTPRD as a regulator of the glial/neuronal balance during cortical neurodevelopment and highlights the importance of studying glial development to understand the etiology of neurodevelopmental diseases.
dc.fechaingreso.objetodigital2024-04-24
dc.fuente.origenSCOPUS
dc.fuente.origenORCID
dc.identifier.doi10.3389/fcell.2024.1357862
dc.identifier.issn2296-634X
dc.identifier.scopusidSCOPUS_ID:85187902709
dc.identifier.urihttps://doi.org/10.3389/fcell.2024.1357862
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/85327
dc.information.autorucFacultad de Ciencias Biológicas; Cornejo Castillo, Francisca Alejandra; 0000-0001-9280-3430; 156096
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final13
dc.pagina.inicio1
dc.publisherFrontiers Media SA
dc.revistaFrontiers in Cell and Developmental Biology
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAstrocytes
dc.subjectBrain cortex
dc.subjectGlia
dc.subjectGliogenesis
dc.subjectNeural precursor cells
dc.subjectNeurodevelopment
dc.subjectOligodendrocytes
dc.subjectPTPRD
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleNeural conditional ablation of the protein tyrosine phosphatase receptor Delta PTPRD impairs gliogenesis in the developing mouse brain cortex
dc.typeartículo
dc.volumen12
dc.volumen12
sipa.codpersvinculados156096
sipa.trazabilidadSCOPUS;2024-03-24
sipa.trazabilidadORCID;2024-04-22
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