Near-optimal glycemic control in Chilean women with pregestational type-2 diabetes: Persistent macrosomia relates to maternal pre-pregnancy overweight

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dc.contributor.authorOlmos, Pablo R.
dc.contributor.authorAraya Del Pino, Andrea P.
dc.contributor.authorGonzalez Carvello, Cristian A.
dc.contributor.authorLaso Ulloa, Pablo
dc.contributor.authorHodgson, Maria I.
dc.contributor.authorIrribarra, Veronica
dc.contributor.authorBorzone, Gisella R.
dc.contributor.authorBelmar, Cristian
dc.contributor.authorPoblete, Andres
dc.contributor.authorBerrios, Cecilia
dc.contributor.authorBecker, Jorge
dc.contributor.authorZajer Amar, Claudia M.
dc.contributor.authorManzur, Alejandro
dc.contributor.authorBozinovic, Milan
dc.contributor.authorMiranda, Ramon J.
dc.contributor.authorDiez, Alberto
dc.contributor.authorVidal, Hernan
dc.contributor.authorRamirez Armijo, Renato
dc.contributor.authorOlmos, Roberto I.
dc.contributor.authorTabilo, Cristian
dc.contributor.authorAhuad, Jessica
dc.date.accessioned2024-01-10T13:15:23Z
dc.date.available2024-01-10T13:15:23Z
dc.date.issued2009
dc.description.abstractAfter a 10-year program intending to improve glycemic control in diabetic pregnancies, we evaluated whether factors underlying macrosomia are similar for type-1 and -2 pregestational diabetic women.
dc.description.abstractPatients and methods: Twenty-three pregnancies in type-1 diabetics (PDM1, age 28.3 +/- 1.1 years) and 51 pregnancies in type-2 diabetics (PDM2, age 32.8 +/- 0.6 years) were followed and treated with intensified insulin therapy. Several factors potentially influencing macrosomia were evaluated. Statistics: chi-square, Fisher's exact, Student's "t" and Mann-Whitney "U" tests, and ROC analysis.
dc.description.abstractResults: In PDM1 and PDM2, respectively, large-for-gestational-age (LGA) frequencies were 26.08% and 37.25% (NS), antepartum. HbA1c values were 6.5 +/- 0.32 and 6.1 +/- 0.16 (NS), and pre-pregnancy body mass indexes (BMI) were 23.03 +/- 0.66 and 30.01 +/- 0.89 (p < 0.0001). In PDM1 the main predictor of LGA was an antepartum HbA1c >= 6.8% (p = 0.046), whereas in PDM2 pregestational BMI >= 24 the variable associated (p = 0.032) with LGA newborns.
dc.description.abstractConclusions: PDM1 and PDM2 differ in the underlying factors related to macrosomia. Whereas in PDM1 the antepartum. HbA1c emerged as the most significant variable, suggesting that glycemic control largely determines macrosomia, in PDM2 with near-optimal glycemic control, macrosomia related to pregestational BMI. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
dc.fechaingreso.objetodigital2024-04-09
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.diabres.2009.04.015
dc.identifier.issn0168-8227
dc.identifier.pubmedidMEDLINE:19446354
dc.identifier.urihttps://doi.org/10.1016/j.diabres.2009.04.015
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78497
dc.identifier.wosidWOS:000267913300010
dc.information.autorucMedicina;Ahuad J;S/I;10369
dc.information.autorucMedicina;Araya-Del-Pino AP;S/I;132727
dc.information.autorucMedicina;Becker J ;S/I;4112
dc.information.autorucMedicina;Belmar C ;S/I;82096
dc.information.autorucMedicina;Berrios C;S/I;77857
dc.information.autorucMedicina;Borzone GR;S/I;99892
dc.information.autorucMedicina;Bozinovic M ;S/I;163778
dc.information.autorucMedicina;Diez A;S/I;156258
dc.information.autorucMedicina;Gonzalez-Carvallo CA ;S/I;132736
dc.information.autorucMedicina;Hodgson MI ;S/I;99461
dc.information.autorucMedicina;Irribarra V ;S/I;366
dc.information.autorucMedicina;Laso-Ulloa P;S/I;132726
dc.information.autorucMedicina;Manzur A ;S/I;57590
dc.information.autorucMedicina;Miranda RJ ;S/I;163707
dc.information.autorucMedicina;Olmos PR ;S/I;98949
dc.information.autorucMedicina;Olmos RI ;S/I;163754
dc.information.autorucMedicina;Poblete A ;S/I;1001584
dc.information.autorucMedicina;Ramirez-Armijo R;S/I;170026
dc.information.autorucMedicina;Tabilo C;S/I;182435
dc.information.autorucMedicina;Zajer-Amar CM ;S/I;8911
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final60
dc.pagina.inicio53
dc.publisherELSEVIER IRELAND LTD
dc.revistaDIABETES RESEARCH AND CLINICAL PRACTICE
dc.rightsacceso restringido
dc.subjectDiabetes
dc.subjectPregestational
dc.subjectMacrosomia
dc.subjectOverweight
dc.subjectINSULIN THERAPY
dc.subjectPREGNANT-WOMEN
dc.subjectBIRTH-WEIGHT
dc.subjectMELLITUS
dc.subjectCHALLENGE
dc.subjectLEPTIN
dc.subjectGROWTH
dc.subjectLIPIDS
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleNear-optimal glycemic control in Chilean women with pregestational type-2 diabetes: Persistent macrosomia relates to maternal pre-pregnancy overweight
dc.typeartículo
dc.volumen85
sipa.codpersvinculados10369
sipa.codpersvinculados132727
sipa.codpersvinculados4112
sipa.codpersvinculados82096
sipa.codpersvinculados77857
sipa.codpersvinculados99892
sipa.codpersvinculados163778
sipa.codpersvinculados156258
sipa.codpersvinculados132736
sipa.codpersvinculados99461
sipa.codpersvinculados366
sipa.codpersvinculados132726
sipa.codpersvinculados57590
sipa.codpersvinculados163707
sipa.codpersvinculados98949
sipa.codpersvinculados163754
sipa.codpersvinculados1001584
sipa.codpersvinculados170026
sipa.codpersvinculados182435
sipa.codpersvinculados8911
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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