Molecular Insights on Shigellosis: How the Interaction Between Invasin IpaA and Vinculin Hijacks Cellular Mechanotransduction

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dc.catalogadorjca
dc.contributor.authorBertocchi , Cristina
dc.contributor.authorMorales, Nicole
dc.contributor.authorRavasio, Andrea
dc.date.accessioned2024-02-27T16:02:46Z
dc.date.available2024-02-27T16:02:46Z
dc.date.issued2023
dc.description.abstractWith 270 million infections annually and nearly half a million death a year, shigellosis is a severe intestinal infection caused by bacteria of the Shigella family. Appearance and spread of drug-resistant strains renewed global concerns for public health and finding novel targets for treatment is fast becoming a priority. To this end, invasins are a potentially good candidate. Also called Ipa(s), which is the short for Invasion Plasmid Antigen, invasins play a key role in mediating bacterial invasion and infection of the host cell. Importantly, they have been reported to hijack inbuilt mechanical capability of the host cells such as cell adhesion and active processes mediated by the actin cytoskeleton to enable bacterial ingress into the host cells. IpaA is an invasin of particular interest as it presents three motifs that mimic vinculin binding sites and thus it allows IpaA to interact with vinculin, which is one of the most critical regulators of cellular and tissue mechanics. Using a mechanobiology point-of-view, we aim to provide an overview of Shigella´s infection mechanism, to highlight recently discovered molecular mechanisms of IpaA/vinculin interaction and to finally discuss their consequences for epithelial cell and tissue mechanical homeostasis that may result in the symptomatic outcomes seen in severe shigellosis.
dc.fechaingreso.objetodigital2024-05-27
dc.fuente.origenORCID
dc.identifier.doi10.33594/000000631
dc.identifier.urihttps://doi.org/10.33594/000000631
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81337
dc.information.autorucFacultad de Ciencias Biológicas; Bertocchi , Cristina; 0000-0003-0907-1318; 1078032
dc.information.autorucFacultad de Ciencias Biológicas;Morales, Nicole;S/I;250242
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final98
dc.pagina.inicio89
dc.revistaParacelsus Proceedings of Experimental Medicine
dc.rightsacceso abierto
dc.subjectShigella
dc.subjectIpaA
dc.subjectVinculin
dc.subjectVinculin binding site (VBS)
dc.subjectMolecular mechanics
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMolecular Insights on Shigellosis: How the Interaction Between Invasin IpaA and Vinculin Hijacks Cellular Mechanotransduction
dc.typeartículo
sipa.codpersvinculados1078032
sipa.codpersvinculados250242
sipa.trazabilidadORCID;2024-01-15
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