Tissue kallikrein in human placenta in early and late gestation

Simple item page
dc.contributor.authorValdés, G
dc.contributor.authorChacón, C
dc.contributor.authorCorthorn, J
dc.contributor.authorFigueroa, CD
dc.contributor.authorGermain, AM
dc.date.accessioned2025-01-21T01:30:56Z
dc.date.available2025-01-21T01:30:56Z
dc.date.issued2001
dc.description.abstractThis study was addressed to identify kallikrein mRNA and protein in early, preterm, and term human placenta and to evaluate their temporospatial pattern. Kallikrein mRNA was expressed in syncytio/cytotrophoblasts and in the endothelial cells of the floating villi, with a greater intensity in early samples (isolated spontaneous abortions and ectopic pregnancies). Cytotrophoblasts at the base of the anchoring villi, maternal decidua and decidual arteries, endothelial cells of chorionic and basal plate blood vessels, and the amniotic epithelium presented a positive signal. Tissue kallikrein was predominantly observed in syncytiotrophoblasts and had a greater immunoreactivity in first-trimester samples. Intraarterial trophoblasts, blood vessels of the floating villi, basal and chorionic plates, and the amniotic epithelium showed positive immunoreactivity. The sites and variations of the tissue kallikrein mRNA and protein in the human placenta, in different stages of pregnancy, support the hypothesis that this enzyme may participate in the establishment and maintenance of placental blood flow through vasodilation, platelet antiaggregation, cell proliferation, and trophoblast invasion.
dc.fuente.origenWOS
dc.identifier.issn0969-711X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96934
dc.identifier.wosidWOS:000168629700008
dc.issue.numero2
dc.language.isoen
dc.pagina.final204
dc.pagina.inicio197
dc.revistaEndocrine
dc.rightsacceso restringido
dc.subjecttissue kallikrein
dc.subjecthuman placenta
dc.subjectpregnancy
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTissue kallikrein in human placenta in early and late gestation
dc.typeartículo
dc.volumen14
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas