Syndecan-1 regulates BMP signaling and dorso-ventral patterning of the ectoderm during early Xenopus development

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dc.contributor.authorOlivares, Gonzalo H.
dc.contributor.authorCarrasco, Hector
dc.contributor.authorAroca, Francisco
dc.contributor.authorCarvallo, Loreto
dc.contributor.authorSegovia, Fabian
dc.contributor.authorLarrain, Juan
dc.date.accessioned2024-01-10T12:43:16Z
dc.date.available2024-01-10T12:43:16Z
dc.date.issued2009
dc.description.abstractExtracellular regulation of growth factor signaling is a key event for embryonic patterning. Heparan sulfate proteoglycans (HSPG) are among the molecules that regulate this signaling during embryonic development. Here we study the function of syndecan1 (Syn1), a cell-surface HSPG expressed in the non-neural ectoderm during early development of Xenopus embryos. Overexpression of Xenopus Syn1 (xSyn1) mRNA is Sufficient to reduce BMP signaling, induce chordin expression and rescue dorso-ventral patterning in ventrailized embryos. Experiments using chordin morpholinos established that xSyn1 mRNA can inhibit BM P signaling in the absence of chordin. Knockdown of xSyn1 resulted in a reduction of BMP signaling and expansion of the neural plate with the concomitant reduction of the non-neural ectoderm. Overexpression of xSyn1 mRNA in xSyn1 morphant embryos resulted in a biphasic effect, with BMP being inhibited at high concentrations and activated at low concentrations of xSyn1. Interestingly, the function of xSyn1 on dorso-ventral patterning and BMP signaling is specific for this HSPG. In summary, we report that xSyn1 regulates dorso-ventral patterning of the ectoderm through modulation of BMP signaling. (C) 2009 Elsevier Inc. All rights reserved.
dc.description.funderFondo Nacional de Ciencia y Tecnologia
dc.fechaingreso.objetodigital17-04-2024
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ydbio.2009.03.007
dc.identifier.eissn1095-564X
dc.identifier.issn0012-1606
dc.identifier.pubmedidMEDLINE:19303002
dc.identifier.urihttps://doi.org/10.1016/j.ydbio.2009.03.007
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77580
dc.identifier.wosidWOS:000266048300015
dc.information.autorucCiencias Biológicas;Aroca F;S/I;160021
dc.information.autorucCiencias Biológicas;Carrasco H ;S/I;7258
dc.information.autorucCiencias Biológicas;Carvallo L ;S/I;167863
dc.information.autorucCiencias Biológicas;Larrain J;S/I;90468
dc.information.autorucCiencias Biológicas;Olivares GH;S/I;13107
dc.information.autorucCiencias Biológicas;Segovia F;S/I;1004561
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final349
dc.pagina.inicio338
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.revistaDEVELOPMENTAL BIOLOGY
dc.rightsacceso restringido
dc.subjectSyndecan1
dc.subjectHSPG
dc.subjectBMP signaling
dc.subjectDorso-ventral patterning
dc.subjectEctoderm
dc.subjectChordin
dc.subjectHEPARAN-SULFATE PROTEOGLYCANS
dc.subjectBONE MORPHOGENETIC PROTEIN-2
dc.subjectSPEMANN ORGANIZER
dc.subjectTWISTED GASTRULATION
dc.subjectEXTENSION MOVEMENTS
dc.subjectINTEGRIN ACTIVITY
dc.subjectAXIS FORMATION
dc.subjectBINDING
dc.subjectCHORDIN
dc.subjectGROWTH
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSyndecan-1 regulates BMP signaling and dorso-ventral patterning of the ectoderm during early Xenopus development
dc.typeartículo
dc.volumen329
sipa.codpersvinculados160021
sipa.codpersvinculados7258
sipa.codpersvinculados167863
sipa.codpersvinculados90468
sipa.codpersvinculados13107
sipa.codpersvinculados1004561
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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