Seeing Double A Comparison of Microstructure, Biomechanical Function, and Adjacent Disc Health Between Double- and Single-Layer Vertebral Endplates

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dc.contributor.authorFields, Aaron J.
dc.contributor.authorSahli, Francisco
dc.contributor.authorRodriguez, Azucena G.
dc.contributor.authorLotz, Jeffrey C.
dc.date.accessioned2024-01-10T12:08:25Z
dc.date.available2024-01-10T12:08:25Z
dc.date.issued2012
dc.description.abstractStudy design. Experimental and computational assessment of thickness, porosity, biomechanical behavior, and adjacent disc glycosaminoglycan content in double- and single-layer bony endplate samples harvested from human cadaver spines.
dc.description.abstractObjective. To determine if the second layer of bone in double-layer vertebral endplates allows the superficial layer to achieve a more optimal balance between its biomechanical and nutritional functions.
dc.description.abstractSummary of Background Data. Proper disc health requires the endplate to balance opposing biomechanical and nutritional functions. Previous studies investigating endplate function report seeing double: some endplates have a second layer of bone. However, it remains unclear whether the second layer of bone has any functional advantage. Such information could shed light on the factors that protect against disc degeneration.
dc.description.abstractMethods. Six lumbar spines were obtained from human cadavers (32-84 yr) and scanned with magnetic resonance imaging. Cylindrical cores that included the endplate and underlying trabecular bone were harvested from the center of the superior vertebral endplates (6 double-and 12 single-layer endplates) and imaged using micro-computed tomography. The thickness and porosity of the bony endplate layers were measured for each core. High-resolution finite element analysis was performed to assess biomechanical behavior. Glycosaminoglycan content within the adjacent nucleus tissue was quantified using the dimethylmethylene blue technique.
dc.description.abstractResults. The superficial layer of the double-layer endplates was 50% thinner (P = 0.009) and tended also to be more porous than single-layer endplates. Strains were higher in thinner endplates; however, the second layer of bone in the double-layer endplates had a stiffening effect so that despite being thinner than single-layer endplates, the superficial layer of the double-layer endplates had a similar risk of damage. After adjusting for age, glycosaminoglycan content was significantly higher in the nucleus tissue adjacent to the double-layer endplates (P = 0.01).
dc.description.abstractConclusion. Compared with single-layer endplates, double-layer endplates seem to permit a more optimal balance between endplate biomechanical and nutritional functions, and may therefore offer a significant protective factor against disc degeneration.
dc.description.funderNational Institutes of Health
dc.description.funderNational Science Foundation
dc.description.funderNATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
dc.fechaingreso.objetodigital2024-05-16
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/BRS.0b013e318267bcfc
dc.identifier.eissn1528-1159
dc.identifier.issn0362-2436
dc.identifier.pubmedidMEDLINE:22781006
dc.identifier.urihttps://doi.org/10.1097/BRS.0b013e318267bcfc
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76391
dc.identifier.wosidWOS:000309550600002
dc.information.autorucIngeniería;Sahli F;S/I;154857
dc.issue.numero21
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaSPINE
dc.rightsacceso restringido
dc.subjectdisc degeneration
dc.subjectendplate
dc.subjectthickness
dc.subjectporosity
dc.subjectspine biomechanics
dc.subjectLUMBAR INTERVERTEBRAL DISC
dc.subjectFINITE-ELEMENT MODELS
dc.subjectTRABECULAR BONE
dc.subjectSTRUCTURAL-PROPERTIES
dc.subjectHYDROSTATIC-PRESSURE
dc.subjectEXTRACELLULAR-MATRIX
dc.subjectNUCLEUS PULPOSUS
dc.subjectDEGENERATION
dc.subjectSPINE
dc.subjectCARTILAGE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSeeing Double A Comparison of Microstructure, Biomechanical Function, and Adjacent Disc Health Between Double- and Single-Layer Vertebral Endplates
dc.typeartículo
dc.volumen37
sipa.codpersvinculados154857
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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