Management of septic shock with a norepinephrine-based haemodynamic algorithm

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dc.contributor.authorHernandez, G
dc.contributor.authorBruhn, A
dc.contributor.authorRomero, C
dc.contributor.authorLarrondo, FJ
dc.contributor.authorDe La Fuente, R
dc.contributor.authorCastillo, L
dc.contributor.authorBugedo, G
dc.date.accessioned2024-01-10T12:40:11Z
dc.date.available2024-01-10T12:40:11Z
dc.date.issued2005
dc.description.abstractManagement of septic shock (SS) with a norepinephrine (noradrenaline)-based haemodynamic algorithm. Introduction: The choice of the best vasopressor for haemodynamic management of septic shock is controversial. Nevertheless, very few studies have been focused on evaluating different management algorithms. The aim of this study was to evaluate the performance of a norepinephrine (NE)-based management protocol. Experience with NE as the initial vasopressor, even if not comparative, could bring relevant data for planning future trails. We also wanted to evaluate the compliance of critical care physicians and nurses with haemodynamic management protocol.
dc.description.abstractPatients and method: A norepinephrine-based algorithm for the management of septic shock that commands different sequential interventions according to its requirements, was applied prospectively to 100 consecutive septic shock patients.
dc.description.abstractResults: Norepinephrine was used as the first vasoactive drug in all patients with a maximum dose of 0.31 +/- 0.3 mu g kg(-1) min(-1) and an ICU mortality of 33%. Physicians applied correctly all the steps of the algorithm in 92% of the patients. Applying the algorithm, avoided the use of pulmonary arthery catheter in 31 patients and led to use of lower doses of vasoactive agents than in many other clinical experiences.
dc.description.abstractConclusion: In conclusion, our data support extended use of an algorithm based on norepinephrine for treating septic shock patients. This is the first clinical study that uses NE as the initial vasopressor drug systematically, and although not comparative, the mortality rates adjusted to APACHE II, are comparable to other studies. It also gives support for future clinical trials comparing norepinephrine with dopamine in this setting. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
dc.fechaingreso.objetodigital09-04-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.resuscitation.2005.01.009
dc.identifier.eissn1873-1570
dc.identifier.issn0300-9572
dc.identifier.pubmedidMEDLINE:15993731
dc.identifier.urihttps://doi.org/10.1016/j.resuscitation.2005.01.009
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77282
dc.identifier.wosidWOS:000230825000010
dc.information.autorucMedicina;Bruhn A;S/I;741
dc.information.autorucMedicina;Bugedo G;S/I;60490
dc.information.autorucMedicina;Hernández G;S/I;98874
dc.information.autorucFacultad de Medicina; De La Fuente Sanhueza, Rene Francisco; S/I; 102089
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final69
dc.pagina.inicio63
dc.publisherELSEVIER IRELAND LTD
dc.revistaRESUSCITATION
dc.rightsacceso restringido
dc.subjectcatecholamines
dc.subjectnorepinephrine
dc.subjectseptic shock
dc.subjectGOAL-DIRECTED THERAPY
dc.subjectDOSE DOPAMINE
dc.subjectSEVERE SEPSIS
dc.subjectMULTICENTER
dc.subjectDOBUTAMINE
dc.subjectMORTALITY
dc.subjectPERFUSION
dc.subjectPRESSURE
dc.subjectSUPPORT
dc.subjectSAFETY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleManagement of septic shock with a norepinephrine-based haemodynamic algorithm
dc.typeartículo
dc.volumen66
sipa.codpersvinculados741
sipa.codpersvinculados60490
sipa.codpersvinculados98874
sipa.codpersvinculados102089
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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