¿Influye el medio de preservación del injerto en los resultados y costos del trasplante hepático de donante fallecido? Comparación de dos soluciones de preservación

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dc.catalogadorgjm
dc.contributor.authorMartínez Castillo, Jorge
dc.contributor.authorBächler, Jean P.
dc.contributor.authorMoisan Paravic, Fabrizio Robertino
dc.contributor.authorTorres Montes, Paula Javiera
dc.contributor.authorDuarte, Ignacio
dc.contributor.authorPérez Ayuso, Rosa María
dc.contributor.authorBenítez Gajardo, Carlos Esteban
dc.contributor.authorArrese, Marco
dc.contributor.authorDomínguez, Pilar
dc.contributor.authorGuerra Castro, Juan Francisco
dc.contributor.authorJarufe Cassis, Nicolás
dc.date.accessioned2025-02-24T16:52:37Z
dc.date.available2025-02-24T16:52:37Z
dc.date.issued2014
dc.description.abstractBackground: Preservation solutions are critical for organ transplantation. In liver transplant (LT), the solution developed by the University Of Wisconsin (UW) is the gold-standard to perfuse deceased brain death donor (DBD) grafts. Histidine-Tryptophan-Ketoglutarate (HTK), formerly a cardioplegic infusion, has been also used in solid organ transplantation. Aim: To compare the outcomes of LT in our center using either HTK or UW solution. Patients and Methods: Retrospective study including 93 LT DBD liver grafts in 89 patients transplanted between March 1994 and July 2010. Forty-eight grafts were preserved with UW and 45 with HTK. Donor and recipient demographics, total infused volume, cold ischemia time, post-reperfusion biopsy, liver function tests, incidence of biliary complications, acute rejection and 12-month graft and patient survival were assessed. Preservation solution costs per liver graft were also recorded. Results: Donor and recipient demographics were similar. When comparing UW and HTK, no differences were observed in cold ischemia time (9.6 ± 3 and 8.7 ± 2 h respectively, p = 0.23), biliary complications, the incidence of acute rejection, primary or delayed graft dysfunction. Histology on post-reperfusion biopsies revealed no differences between groups. The infused volume was significantly higher with HTK than with UW (9 (5-16) and 6 (3-11) l, p < 0.001). The cost per procurement was remarkably lower using HTK. Conclusions: Perfusion of DBD liver grafts with HTK is clinically equivalent to UW, with a significant cost reduction.
dc.fechaingreso.objetodigital2025-02-24
dc.format.extent9 páginas
dc.fuente.origenRepositorio UC
dc.identifier.doi10.4067/S0034-98872014001000001
dc.identifier.issn0034-9887
dc.identifier.issn0717-6163
dc.identifier.urihttp://dx.doi.org/10.4067/S0034-98872014001000001
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102215
dc.information.autorucEscuela de Medicina; Martínez Castillo, Jorge; 0000-0001-5823-7308; 65778
dc.information.autorucEscuela de Medicina; Bächler, Jean P.; S/I; 199936
dc.information.autorucEscuela de Medicina; Moisan Paravic, Fabrizio Robertino; S/I; 175122
dc.information.autorucEscuela de Medicina; Torres Montes, Paula Javiera; 0000-0001-9979-4223; 95391
dc.information.autorucEscuela de Medicina; Duarte, Ignacio; S/I; 98528
dc.information.autorucEscuela de Medicina; Pérez Ayuso, Rosa María; S/I; 100479
dc.information.autorucEscuela de Medicina; Benítez Gajardo, Carlos Esteban; S/I; 9202
dc.information.autorucEscuela de Medicina; Arrese, Marco; 0000-0002-0499-4191; 76095
dc.information.autorucEscuela de Medicina; Guerra Castro, Juan Francisco; S/I; 159745
dc.information.autorucEscuela de Medicina; Jarufe Cassis, Nicolás; S/I; 104492
dc.issue.numero10
dc.language.isoes
dc.nota.accesocontenido completo
dc.pagina.final1237
dc.pagina.inicio1229
dc.revistaRevista Médica de Chile
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCost-benefit analysis
dc.subjectLiver transplantation
dc.subjectOrgan preservation solutions
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.title¿Influye el medio de preservación del injerto en los resultados y costos del trasplante hepático de donante fallecido? Comparación de dos soluciones de preservación
dc.title.alternativeOutcomes using two preservation solutions (UW/HTK) in liver transplantation from brain death donors
dc.typeartículo
dc.volumen142
sipa.codpersvinculados78794
sipa.codpersvinculados65778
sipa.codpersvinculados199936
sipa.codpersvinculados175122
sipa.codpersvinculados95391
sipa.codpersvinculados98528
sipa.codpersvinculados100479
sipa.codpersvinculados9202
sipa.codpersvinculados76095
sipa.codpersvinculados159745
sipa.codpersvinculados104492
sipa.trazabilidadConveris;01-10-2020
sipa.trazabilidadRepositorio UC;08-07-2021
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