Molecular changes in the bronchial epithelium of patients with small cell lung cancer

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dc.contributor.authorWistuba, II
dc.contributor.authorBerry, J
dc.contributor.authorBehrens, C
dc.contributor.authorMaitra, A
dc.contributor.authorShivapurkar, N
dc.contributor.authorMilchgrub, S
dc.contributor.authorMackay, B
dc.contributor.authorMinna, JD
dc.contributor.authorGazdar, AF
dc.date.accessioned2024-01-10T12:40:34Z
dc.date.available2024-01-10T12:40:34Z
dc.date.issued2000
dc.description.abstractTo better understand the pathways involved in the pathogenesis of small cell lung carcinoma (SCLC), we compared the patterns of molecular changes present in these tumors and their accompanying bronchial epithelium with those present in the other two major types of lung cancer [squamous cell carcinoma (SQC) and adenocarcinoma (ADC)I, We obtained DNA from 68 microdissected invasive lung tumors (22 SCLCs, 21 ADCs, and, 25 SQCs) and 119 noncontiguous foci of histologically normal or hyperplastic epithelia from 10 tumors of each histological type. We determined loss of heterozygosity and microsatellite alterations at 12 chromosomal regions frequently deleted in lung cancers using 19 polymorphic microsatellite markers. Our major findings are as follows: (a) the mean index of allelic loss in SCLC (0.85) and SQC (0.71) tumors was higher than that in ADC (0.39) tumors; (b) although there was considerable overlap, each tumor type had a characteristic pattern of allelic loss; (c) most samples of bronchial epithelium accompanying SCLC (90%) had allelic loss at one or more loci compared with samples accompanying SQC (54%) or ADC (10%); (d) the mean index of allelic loss was much higher in bronchial epithelial samples from SCLC (0.27) than in those from SQC (0.08) or ADC (0.01); and (e) although the mean indices of microsatellite alterations in the tumor types were similar, the bronchial epithelial samples accompanying SCLC had a 10-fold higher mean index (0.063) than those accompanying SQC (0.006) or ADC (0,006), Our findings indicate that extensive genetic damage in the accompanying normal and hyperplastic bronchial epithelium is characteristic of SCLC tumors and suggest major differences in the pathogenesis of the three major lung cancer types.
dc.description.funderNCI NIH HHS
dc.description.funderNATIONAL CANCER INSTITUTE
dc.fechaingreso.objetodigital2024-06-13
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.issn1078-0432
dc.identifier.pubmedidMEDLINE:10914700
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77324
dc.identifier.wosidWOS:000088147500003
dc.information.autorucMedicina;Wistuba I;S/I;100278
dc.issue.numero7
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final2610
dc.pagina.inicio2604
dc.publisherAMER ASSOC CANCER RESEARCH
dc.revistaCLINICAL CANCER RESEARCH
dc.rightsacceso restringido
dc.subjectFORMER SMOKERS
dc.subjectCARCINOMA
dc.subjectADENOCARCINOMA
dc.subjectPATHOGENESIS
dc.subjectABNORMALITIES
dc.subjectDELETIONS
dc.subjectMUTATIONS
dc.subjectPATTERNS
dc.subjectFREQUENT
dc.subjectSTAGE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMolecular changes in the bronchial epithelium of patients with small cell lung cancer
dc.typeartículo
dc.volumen6
sipa.codpersvinculados100278
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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