Pharmacokinetics of lysine clonixinate in children in postoperative care

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dc.contributor.authorGonzalezMartin, G
dc.contributor.authorCattan, C
dc.contributor.authorZuniga, S
dc.date.accessioned2024-01-10T13:16:12Z
dc.date.available2024-01-10T13:16:12Z
dc.date.issued1996
dc.description.abstractThe pharmacokinetics of 2 doses of intravenous lysine clonixinate (4 and 6 mg x kg(-1)) were studied in 10 children (age 4 - 10 years) under postoperative care, A single dose of the drug was injected in a forearm vein, Blood samples were collected at regular intervals for 3 hours. Serum clonixin concentrations (expressed as clonixin) were analyzed using a high pressure liquid chromatography method, Pharmacokinetic values were estimated by a nonlinear computer program. The distribution volume was similar in both groups of children (1.288 +/- 0.829 1 and 1. 139 +/- 0.667 1, respectively). There were no differences between the values of total plasma clearance and the administered doses (0.026 +/- 0.017 ml x min(-1) and 0.017 +/- 0.008 ml x min(-1), t = 1.07, p = 0.76), The elimination half-life was longer in children who received 6 mg x kg(-1) (44.26 +/- 6.34 min vs 38.63 +/- 10.93 min) but this difference was not statistically significant (t = 0.99, p < 0.34). The pharmacokinetic parameters calculated in these children were different from those found by other authors in adults and experimental animals.
dc.fechaingreso.objetodigital2024-06-14
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.issn0946-1965
dc.identifier.pubmedidMEDLINE:8880290
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78566
dc.identifier.wosidWOS:A1996VG71700007
dc.information.autorucQuímica;González G;S/I;98524
dc.issue.numero9
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final399
dc.pagina.inicio396
dc.publisherDUSTRI-VERLAG DR KARL FEISTLE
dc.revistaINTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
dc.rightsacceso restringido
dc.subjectlysine clonixinate
dc.subjectpharmacokinetic
dc.subjectchildren
dc.subjectpostoperative pain
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePharmacokinetics of lysine clonixinate in children in postoperative care
dc.typeartículo
dc.volumen34
sipa.codpersvinculados98524
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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