Individualized dose of anti-thymocyte globulin based on weight and pre-transplantation lymphocyte counts in pediatric patients: a single center experience

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dc.catalogadorgrr
dc.contributor.authorBarriga, Francisco
dc.contributor.authorWietstruck Pena, Maria Angelica
dc.contributor.authorSchulze Schiappacasse, Clara Edith
dc.contributor.authorCatalan Martinez, Paula Valentina
dc.contributor.authorSotomayor, Cristian
dc.contributor.authorZuñiga Contreras, Pamela Alejandra
dc.contributor.authorAguirre Rioseco, Noemi Doris
dc.contributor.authorVizcaya Altamirano, Maria Cecilia
dc.contributor.authorLe Corre Perez, Monique Nicole
dc.contributor.authorVillarroel, Luis
dc.date.accessioned2024-07-18T19:48:30Z
dc.date.available2024-07-18T19:48:30Z
dc.date.issued2024
dc.description.abstractAnti-thymocyte globulin (ATG) has become a standard in preventing GVHD in related and unrelated donor transplantation, but there is no consensus on the best administration schedule. The PARACHUTE trial reported excellent CD4 immune reconstitution (CD4 IR) using a dosing schedule based on the patient's weight and pre-conditioning absolute lymphocyte count (ALC). In 2015 we introduced the PARACHUTE dosing schedule for pediatric patients at our center. One hundred one patients were transplanted for malignant and non-malignant diseases. In this non-concurrent cohort CD4 IR+, defined by a single CD4 count >50/µL on day 90, was seen in 81% of patients. The incidence of grade II-IV and III to IV aGvHD was 26.6% and 15.3% and 5% for cGvHD with no severe cases. We found no difference in aGvHD between donor type and stem cell sources. Five-year EFS and OS were 77.5% and 83.5%. Grade III-IV GFRS was 75.2%. CD4 IR+ patients had better EFS (93.1% vs. 77.7%, p = 0.04) and lower non-relapse mortality (2.7% vs. 22.2%, p = 0.002). The PARACHUTE ATG dosing schedule individualized by weight and ALC results in good early immune reconstitution, low incidence of cGvHD, and favorable survival for patients with different disease groups, donor types, and stem cell sources.
dc.fechaingreso.objetodigital2024-09-05
dc.fuente.origenSCOPUS
dc.identifier.doi10.1038/s41409-024-02206-5
dc.identifier.eissn1476-5365
dc.identifier.issn1476-5365
dc.identifier.issn0268-3369
dc.identifier.pubmedid38253868
dc.identifier.scopusidSCOPUS_ID:85182825311
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87128
dc.identifier.wosidWOS:001154985200003
dc.information.autorucEscuela de Medicina; Wietstruck Pena, Maria Angelica; S/I; 100463
dc.information.autorucEscuela de Medicina; Schulze Schiappacasse, Clara Edith; S/I; 204900
dc.information.autorucEscuela de Medicina; Catalan Martinez, Paula Valentina; 0000-0002-3365-8816; 1199784
dc.information.autorucEscuela de Medicina; Zuñiga Contreras, Pamela Alejandra; S/I; 115760
dc.information.autorucEscuela de Medicina; Aguirre Rioseco, Noemi Doris; 0000-0003-3529-5702; 218585
dc.information.autorucEscuela de Medicina; Vizcaya Altamirano, Maria Cecilia; 0000-0003-1309-9778; 7645
dc.information.autorucEscuela de Medicina; Le Corre Perez, Monique Nicole; 0000-0002-9361-4049; 6737
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final478
dc.pagina.inicio473
dc.publisherSpringer Nature
dc.revistaBone Marrow Transplantation
dc.rightsacceso restringido
dc.rights.licenseATTRIBUTION 4.0 INTERNATIONAL
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIndividualized dose of anti-thymocyte globulin based on weight and pre-transplantation lymphocyte counts in pediatric patients: a single center experience
dc.typeartículo
dc.volumen59
sipa.codpersvinculados100463
sipa.codpersvinculados204900
sipa.codpersvinculados1199784
sipa.codpersvinculados115760
sipa.codpersvinculados218585
sipa.codpersvinculados7645
sipa.codpersvinculados6737
sipa.trazabilidadSCOPUS;2024-02-04
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