Adiponectin levels, cardiometabolic risk factors and markers of subclinical atherosclerosis in children

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dc.contributor.authorArnaiz, Pilar
dc.contributor.authorAcevedo, Monica
dc.contributor.authorBarja, Salesa
dc.contributor.authorAglony, Marlene
dc.contributor.authorGuzman, Beatriz
dc.contributor.authorCassis, Berta
dc.contributor.authorCarvajal, Jacqueline
dc.contributor.authorMoreno, Manuel
dc.contributor.authorNavarrete, Carlos
dc.contributor.authorBerrios, Ximena
dc.date.accessioned2024-01-10T13:10:54Z
dc.date.available2024-01-10T13:10:54Z
dc.date.issued2010
dc.description.abstractBackground: Low levels of adiponectin have been associated with metabolic risk factors (RF) and cardiac disease. Minimal data is available about the relationship between adiponectin and subclinical atherosclerosis. Objectives: To determine the relationship of adiponectin to cardiometabolic RF, C-reactive protein (CRP), anthropometric parameters of obesity, and subclinical atherosclerosis in children.
dc.description.abstractMethods: Cross-sectional study in 103 children. We determined body mass index (BMI), waist circumference, percent fat mass, systolic and diastolic blood pressures, fasting lipid profile, glycemia and insulinemia, and CRP. Subclinical atherosclerosis was determined by carotid intima-media thickness (IMT) and flow-mediated dilation of the brachial artery (FMD).
dc.description.abstractResults: Mean age of the group was 12.4 +/- 1.9 years (47% girls; 20.4% prepubertal; 45 eutrophic, 23 overweight and 35 obese). Adiponectin levels were not statistically significantly different in eutrophic children versus obese+overweight: 17.7 +/- 5.6 and 15.9 +/- 5.3 mu g/mL, respectively. Adiponectin levels in boys were no different from those in girls. Adiponectin correlated significantly with age, BMI, zBMI, waist circumference, systolic and diastolic blood pressures, HDL, insulinemia, and HOMA index. No statistically significant association with adiponectin was found for CRP, FMD or IMT. After adjusting by sex, pubertal status, and degree of obesity, the adiponectin levels associated significantly with HDL cholesterol and the HOMA index (r(2)=0.34, p<0.0001).
dc.description.abstractConclusions: Adiponectin levels were inversely correlated with anthropometric parameters of obesity and insulin resistance and directly correlated with HDL levels. However, no relationship with subclinical atherosclerosis was demonstrated in this study. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
dc.fechaingreso.objetodigital25-03-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ijcard.2008.08.007
dc.identifier.eissn1874-1754
dc.identifier.issn0167-5273
dc.identifier.pubmedidMEDLINE:18774612
dc.identifier.urihttps://doi.org/10.1016/j.ijcard.2008.08.007
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77957
dc.identifier.wosidWOS:000273613300006
dc.information.autorucMedicina;Acevedo M;S/I;81173
dc.information.autorucMedicina;Aglony M;S/I;1273
dc.information.autorucMedicina;Arnaiz P;S/I;98982
dc.information.autorucMedicina;Barja S;S/I;64532
dc.information.autorucMedicina;Berrios X;S/I;98139
dc.information.autorucMedicina;Carvajal J;S/I;72914
dc.information.autorucMedicina;Moreno M.;S/I;100199
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final144
dc.pagina.inicio138
dc.publisherELSEVIER IRELAND LTD
dc.revistaINTERNATIONAL JOURNAL OF CARDIOLOGY
dc.rightsacceso restringido
dc.subjectAdiponectin
dc.subjectObesity
dc.subjectRisk factors
dc.subjectAtherosclerosis
dc.subjectINTIMA MEDIA THICKNESS
dc.subjectINSULIN-RESISTANCE
dc.subjectINFLAMMATORY MARKERS
dc.subjectOBESE CHILDREN
dc.subjectADIPOSITY
dc.subjectGLUCOSE
dc.subjectFAT
dc.subjectCHILDHOOD
dc.subjectDECREASE
dc.subjectPROTEIN
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAdiponectin levels, cardiometabolic risk factors and markers of subclinical atherosclerosis in children
dc.typeartículo
dc.volumen138
sipa.codpersvinculados81173
sipa.codpersvinculados1273
sipa.codpersvinculados98982
sipa.codpersvinculados64532
sipa.codpersvinculados98139
sipa.codpersvinculados72914
sipa.codpersvinculados100199
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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