Self-nanoemulsifying composition containing curcumin, quercetin, Ganoderma lucidum extract powder and probiotics for effective treatment of type 2 diabetes mellitus in streptozotocin induced rats

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dc.article.number121306
dc.catalogadoryvc
dc.contributor.authorKhursheed, Rubiya
dc.contributor.authorSingh, Sachin Kumar
dc.contributor.authorKumar, Bimlesh
dc.contributor.authorWadhwa, Sheetu
dc.contributor.authorGulati, Mónica
dc.contributor.authorAnupriya, A.
dc.contributor.authorAwasthi, Ankit
dc.contributor.authorVishwas, Sukriti
dc.contributor.authorKaur, Jaskiran
dc.contributor.authorCorrie, Leander
dc.contributor.authorArya, K. R.
dc.contributor.authorKumar, Rajan
dc.contributor.authorJha, Niraj Kumar
dc.contributor.authorGupta, Piyush Kumar
dc.contributor.authorZacconi, Flavia C. M.
dc.contributor.authorDua, Kamal
dc.contributor.authorChitranshi, Nitin
dc.contributor.authorMustafa, Gulam
dc.contributor.authorKumar, Ankit
dc.date.accessioned2023-08-24T20:42:27Z
dc.date.available2023-08-24T20:42:27Z
dc.date.issued2022
dc.description.abstractLiquid self-nanoemulsifying drug delivery system (L-SNEDDS) of curcumin and quercetin were prepared by dissolving them in isotropic mixture of Labrafil M1944CS®, Capmul MCM®, Tween-80® and Transcutol P®. The prepared L-SNEDDS were solidified using Ganoderma lucidum extract, probiotics and Aerosil-200® using spray drying. These were further converted into pellets using extrusion-spheronization. The mean droplet size and zeta potential of L-SNEDDS were found to be 63.46 ± 2.12 nm and − 14.8 ± 3.11 mV while for solid SNEDDS pellets, these were 72.46 ± 2.16 nm and −38.7 ± 1.34 mV, respectively. The dissolution rate for curcumin and quercetin each was enhanced by 4.5 folds while permeability was enhanced by 5.28 folds (curcumin) and 3.35 folds (quercetin) when loaded into SNEDDS pellets. The Cmax for curcumin and quercetin containing SNEDDS pellets was found 532.34 ± 5.64 ng/mL and 4280 ± 65.67 ng/mL, respectively. This was 17.55 and 3.48 folds higher as compared to their naïve forms. About 50.23– and 5.57-folds increase in bioavailability was observed for curcumin and quercetin respectively, upon loading into SNEDDS pellets. SNEDDS pellets were found stable at accelerated storage conditions. The developed formulation was able to normalize the levels of blood glucose, lipids, antioxidant biomarkers, and tissue architecture of pancreas and liver in streptozotocin induced diabetic rats as compared to their naïve forms.
dc.fechaingreso.objetodigital2023-08-24
dc.fuente.origenSCOPUS
dc.identifier.doi10.1016/j.ijpharm.2021.121306
dc.identifier.eissn18733476
dc.identifier.issn0378-5173
dc.identifier.pubmedidMEDLINE_ID:34813906
dc.identifier.scopusidSCOPUS_ID:85120795295
dc.identifier.urihttps://doi.org/10.1016/j.ijpharm.2021.121306
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74490
dc.identifier.wosidWOS:000740100600001
dc.information.autorucEscuela de Química ; Flavia C. Zacconi ; 0000-0002-3676-0453 ; 1011127
dc.language.isoen
dc.nota.accesoContenido parcial
dc.publisherElsevier B.V.
dc.revistaInternational Journal of Pharmaceutics
dc.rightsacceso restringido
dc.subjectCurcumin
dc.subjectMushroom polysaccharide
dc.subjectProbiotics
dc.subjectQuercetin
dc.subjectSNEDDS
dc.subjectDrug-Delivery System
dc.subject.ddc600
dc.subject.deweyTecnologíaes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSelf-nanoemulsifying composition containing curcumin, quercetin, Ganoderma lucidum extract powder and probiotics for effective treatment of type 2 diabetes mellitus in streptozotocin induced rats
dc.typeartículo
dc.volumen612
sipa.codpersvinculados1011127
sipa.indexSCOPUS
sipa.trazabilidadSCOPUS;21-03-2022
sipa.trazabilidadWOS;18-03-2022
sipa.trazabilidadORCID;2023-08-20
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