Use of Real-Time Functional Magnetic Resonance Imaging-Based Neurofeedback to Downregulate Insular Cortex in Nicotine-Addicted Smokers

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dc.contributor.authorRana, Mohit
dc.contributor.authorRuiz, Sergio
dc.contributor.authorSanchez Corzo, Andrea
dc.contributor.authorMuehleck, Axel
dc.contributor.authorEck, Sandra
dc.contributor.authorSalinas, Cesar
dc.contributor.authorZamorano, Francisco
dc.contributor.authorSilva, Claudio
dc.contributor.authorRea, Massimiliano
dc.contributor.authorBatra, Anil
dc.contributor.authorBirbaumer, Niels
dc.contributor.authorSitaram, Ranganatha
dc.date.accessioned2025-01-23T19:50:33Z
dc.date.available2025-01-23T19:50:33Z
dc.date.issued2020
dc.description.abstractIt has been more than a decade since the first functional magnetic resonance imaging (fMRI)-based neurofeedback approach was successfully implemented. Since then, various studies have demonstrated that participants can learn to voluntarily control a circumscribed brain region. Consequently, real-time fMRI (rtfMRI) provided a novel opportunity to study modifications of behavior due to manipulation of brain activity. Hence, reports of rtfMRI applications to train self-regulation of brain activity and the concomitant modifications in behavioral and clinical conditions such as neurological and psychiatric disorders [e.g., schizophrenia, obsessive compulsive Disorder (OCD), stroke] have rapidly increased.
dc.description.abstractNeuroimaging studies in addiction research have shown that the anterior cingulate cortex, orbitofrontal cortex, and insular cortex are activated during the presentation of drug-associated cues. Also, activity in both left and right insular cortices have been shown to be highly correlated with drug urges when participants are exposed to craving-eliciting cues. Hence, the bilateral insula is of particular importance in researching drug urges and addiction due to its role in the representation of bodily (interoceptive) states. This study explores the use of rtfMRI neurofeedback for the reduction in blood oxygen-level dependent (BOLD) activity in bilateral insular cortices of nicotine-addicted participants. The study also tests if there are neurofeedback training-associated modifications in the implicit attitudes of participants towards nicotine-craving cues and explicit-craving behavior.
dc.fuente.origenWOS
dc.identifier.doi10.3791/59441
dc.identifier.issn1940-087X
dc.identifier.urihttps://doi.org/10.3791/59441
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100551
dc.identifier.wosidWOS:000546499200129
dc.issue.numero160
dc.language.isoen
dc.revistaJove-journal of visualized experiments
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleUse of Real-Time Functional Magnetic Resonance Imaging-Based Neurofeedback to Downregulate Insular Cortex in Nicotine-Addicted Smokers
dc.typeartículo
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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