Transdermal penetration of diclofenac in the presence of AAPH-derived peroxyl radicals

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dc.contributor.authorRojo Vergara, C.
dc.contributor.authorLopez Alarcon, C.
dc.contributor.authorAlvarez Figueroa, M. J.
dc.date.accessioned2024-01-10T12:10:21Z
dc.date.available2024-01-10T12:10:21Z
dc.date.issued2009
dc.description.abstractIn vitro transdermal delivery of diclofenac across pig skin in the presence of AAPH-derived peroxyl radicals (2,2'-azo-bis(2-amidinopropane)dihydrochloride) has been studied. The transdermal absorption of diclofenac was estimated using high-performance liquid chromatography after its incubation in vertical cells. The diclofenac transdermal penetration was highly modified by peroxyl radicals. In the presence of AAPH, lower diclofenac absorption was observed. This effect was inhibited by ferulic acid. This could be explained by diclofenac-peroxyl radical interactions. In the pretreatment skin with AAPH, lower diclofenac absorption was higher than control experiments. This behavior should be considered in the topical administration of pharmaceutical preparations containing diclofenac.
dc.description.funderFaculty of Chemistry of Pontificia Universidad Catolica de Chile
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2024-05-08
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1080/03639040902737484
dc.identifier.eissn1520-5762
dc.identifier.issn0363-9045
dc.identifier.pubmedidMEDLINE:19360512
dc.identifier.urihttps://doi.org/10.1080/03639040902737484
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76569
dc.identifier.wosidWOS:000268879400010
dc.information.autorucQuímica;López-Alarcón C;S/I;1004308
dc.information.autorucQuímica;Rojo-Vergara C;S/I;120489
dc.information.autorucQuímica;Álvarez-Figueroa MJ;S/I;70358
dc.issue.numero8
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final980
dc.pagina.inicio976
dc.publisherTAYLOR & FRANCIS LTD
dc.revistaDRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
dc.rightsacceso restringido
dc.subjectAAPH
dc.subjectabsorption
dc.subjectdiclofenac
dc.subjectperoxyl radicals
dc.subjecttransdermal
dc.subjectCINNAMIC ACID-DERIVATIVES
dc.subjectIN-VITRO
dc.subjectFERULIC ACID
dc.subjectOXIDATIVE STRESS
dc.subjectDRUG
dc.subjectDELIVERY
dc.subjectPROTECTION
dc.subjectSYSTEMS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTransdermal penetration of diclofenac in the presence of AAPH-derived peroxyl radicals
dc.typeartículo
dc.volumen35
sipa.codpersvinculados1004308
sipa.codpersvinculados120489
sipa.codpersvinculados70358
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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