Preparation and bioactive properties of novel bone-repair bionanocomposites based on hydroxyapatite and bioactive glass nanoparticles

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dc.contributor.authorValenzuela, Francisco
dc.contributor.authorCovarrubias, Cristian
dc.contributor.authorMartinez, Constanza
dc.contributor.authorSmith, Patricio
dc.contributor.authorDiaz Dosque, Mario
dc.contributor.authorYazdani Pedram, Mehrdad
dc.date.accessioned2024-01-10T13:52:28Z
dc.date.available2024-01-10T13:52:28Z
dc.date.issued2012
dc.description.abstractBionanocomposites based on ceramic nanoparticles and a biodegradable porous matrix represent a promising strategy for bone repair applications. The preparation and bioactive properties of bionanocomposites based on hydroxyapatite (nHA) and bioactive glass (nBG) nanoparticles were presented. nHA and nBG were synthesized with nanometric particle size using solgel/precipitation methods. Composite scaffolds were prepared by incorporating nHA and nBG into a porous alginate (ALG) matrix at different particle loads. The ability of the bionanocomposites to induce the crystallization of the apatite phase from simulated body fluid (SBF) was systematically evaluated using X-ray diffraction (XRD), scanning electron microscopy with energy dispersive X-ray analysis, and Fourier transform infrared spectroscopy. Both nHA/ALG and nBG/ALG composites were shown to notably accelerate the process of crystallization and growth of the apatite phase on the scaffold surfaces. For short immersion times in SBF, nBG (25%)-based nanocomposites induced a higher degree of apatite crystallization than nHA (25%)-based nanocomposites, probably due to the more reactive nature of the BG particles. Through a reinforcement effect, the nanoparticles also improve the mechanical properties and stability in SBF of the polymer scaffold matrix. In addition, in vitro biocompatibility tests demonstrated that osteoblast cells are viable and adhere well on the surface of the bionanocomposites. These results indicate that nHA- and nBG-based bionanocomposites present potential properties for bone repair applications, particularly oriented to accelerate the bone mineralization process. (c) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 16721682, 2012.
dc.description.funderCONICYT
dc.description.funderVicerrectoria de Investigacion y Desarrollo (VID)-Universidad de Chile (Faculty Travel Grant Program "U-Apoya: Linea Ayuda de Viaje'')
dc.fechaingreso.objetodigital2024-04-27
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/jbm.b.32736
dc.identifier.eissn1552-4981
dc.identifier.issn1552-4973
dc.identifier.pubmedidMEDLINE:22707209
dc.identifier.urihttps://doi.org/10.1002/jbm.b.32736
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79665
dc.identifier.wosidWOS:000305972800024
dc.information.autorucMedicina;Martinez C ;S/I;1008613
dc.information.autorucMedicina;Smith P;S/I;1006488
dc.issue.numero6
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1682
dc.pagina.inicio1672
dc.publisherWILEY
dc.revistaJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
dc.rightsacceso restringido
dc.subjectbioactive nanoparticles
dc.subjectbionanocomposites
dc.subjectbioactive glass
dc.subjecthydroxyapatite
dc.subjectbone regeneration
dc.subjectALGINATE
dc.subjectSCAFFOLDS
dc.subjectCHITOSAN
dc.subjectNANOCOMPOSITES
dc.subjectPHOSPHATE
dc.subjectSURFACES
dc.subjectSILICON
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePreparation and bioactive properties of novel bone-repair bionanocomposites based on hydroxyapatite and bioactive glass nanoparticles
dc.typeartículo
dc.volumen100
sipa.codpersvinculados1008613
sipa.codpersvinculados1006488
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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