Prevalence of antiphospholipid and antiplatelet antibodies in human immunodeficiency virus (HIV)-infected Chilean patients

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dc.contributor.authorPalomo, I
dc.contributor.authorAlarcon, M
dc.contributor.authorSepulveda, C
dc.contributor.authorPereira, J
dc.contributor.authorEspinola, R
dc.contributor.authorPierangeli, S
dc.date.accessioned2024-01-10T13:52:30Z
dc.date.available2024-01-10T13:52:30Z
dc.date.issued2003
dc.description.abstractAntiphospholipid (aPL) and antiplatelet (aPlt) antibodies, found in patients with autoimmune diseases, are also detected in infectious diseases. The purpose of this study was to examine the prevalence of these antibodies in HIV patients and to evaluate an association of these antibodies with thrombocytopenia and/or thrombosis. Sixty-three HIV-seropositive patients and 52 normal controls were studied. Anticardiolipin (aCL), anti-beta(2) glycoprotein I (anti-beta(2)GPI), and antiprothrombin (aPT) antibodies were determined and the lupus anticoagulant (LA) test was performed. Antiplatelet antibodies (aPlt) were also determined. Seven out of 63 (12.7%) HIV patients were positive for aCL, four of 63 (6.3%) for anti-beta(2)GPI, and five of 63 (7.9%) for aPT. No patients studied were LA positive. Six out of 63 (9.5%) patients were positive for aPlt. One of them showed weak reactivity for GPIb-IX. The platelet count of patients (202 +/- 63 x 10(3) platelets/muL) was significantly lower than in the controls (343+/-6 x 10(3) platelets/muL) (P<0.001). There was no correlation between the presence of aPL and/or aPlt and thrombocytopenia. Of the HIV-infected patients, 22.2% presented aPL and 9.4% aPlt antibodies. In this study, the presence of aPL and aPlt antibodies was not associated with the development of thrombosis and/or thrombocytopenia. (C) 2003 Wiley-Liss, Inc.
dc.fechaingreso.objetodigital2024-04-27
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/jcla.10093
dc.identifier.eissn1098-2825
dc.identifier.issn0887-8013
dc.identifier.pubmedidMEDLINE:14614742
dc.identifier.urihttps://doi.org/10.1002/jcla.10093
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79667
dc.identifier.wosidWOS:000186954800002
dc.information.autorucMedicina;Pereira J;S/I;99371
dc.issue.numero6
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final215
dc.pagina.inicio209
dc.publisherWILEY
dc.revistaJOURNAL OF CLINICAL LABORATORY ANALYSIS
dc.rightsacceso restringido
dc.subjectHIV infection
dc.subjectantiphospholipid antibodies
dc.subjectantiplatelet antibodies
dc.subjectanticardiolipin
dc.subjectantibodies
dc.subjectANTI-BETA-2 GLYCOPROTEIN-I
dc.subjectANTICARDIOLIPIN ANTIBODIES
dc.subjectBETA(2)-GLYCOPROTEIN I
dc.subjectLUPUS ANTICOAGULANT
dc.subjectPLATELET
dc.subjectAUTOANTIBODIES
dc.subjectINFECTION
dc.subjectTHROMBOCYTOPENIA
dc.subjectPHOSPHOLIPIDS
dc.subjectQUANTITATION
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titlePrevalence of antiphospholipid and antiplatelet antibodies in human immunodeficiency virus (HIV)-infected Chilean patients
dc.typeartículo
dc.volumen17
sipa.codpersvinculados99371
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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