Systemic-to-pulmonary collateral flow in patients with palliated univentricular heart physiology: measurement using cardiovascular magnetic resonance 4D velocity acquisition

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dc.contributor.authorValverde, Israel.
dc.contributor.authorUribe Arancibia, Sergio A.
dc.contributor.authorNordmeyer, Sarah.
dc.contributor.authorGreil, Gerald F.
dc.contributor.authorBerger, Felix.
dc.contributor.authorKuehne, Titus.
dc.contributor.authorBeerbaum, Philipp B.
dc.date.accessioned2019-10-17T11:51:19Z
dc.date.available2019-10-17T11:51:19Z
dc.date.issued2012
dc.date.updated2019-10-14T18:58:29Z
dc.description.abstractAbstract Background Systemic-to-pulmonary collateral flow (SPCF) may constitute a risk factor for increased morbidity and mortality in patients with single-ventricle physiology (SV). However, clinical research is limited by the complexity of multi-vessel two-dimensional (2D) cardiovascular magnetic resonance (CMR) flow measurements. We sought to validate four-dimensional (4D) velocity acquisition sequence for concise quantification of SPCF and flow distribution in patients with SV. Methods 29 patients with SV physiology prospectively underwent CMR (1.5 T) (n = 14 bidirectional cavopulmonary connection [BCPC], age 2.9 ± 1.3 years; and n = 15 Fontan, 14.4 ± 5.9 years) and 20 healthy volunteers (age, 28.7 ± 13.1 years) served as controls. A single whole-heart 4D velocity acquisition and five 2D flow acquisitions were performed in the aorta, superior/inferior caval veins, right/left pulmonary arteries to serve as gold-standard. The five 2D velocity acquisition measurements were compared with 4D velocity acquisition for validation of individual vessel flow quantification and time efficiency. The SPCF was calculated by evaluating the disparity between systemic (aortic minus caval vein flows) and pulmonary flows (arterial and venour return). The pulmonary right to left and the systemic lower to upper body flow distribution were also calculated. Results The comparison between 4D velocity and 2D flow acquisitions showed good Bland-Altman agreement for all individual vessels (mean bias, 0.05±0.24 l/min/m2), calculated SPCF (−0.02±0.18 l/min/m2) and significantly shorter 4D velocity acquisition-time (12:34 min/17:28 min,p < 0.01). 4D velocity acquisition in patients versus controls revealed (1) good agreement between systemic versus pulmonary estimator for SPFC; (2) significant SPCF in patients (BCPC 0.79±0.45 l/min/m2; Fontan 0.62±0.82 l/min/m2) and not in controls (0.01 + 0.16 l/min/m2), (3) inverse relation of right/left pulmonary artery perfusion and right/left SPCF (Pearson = −0.47,p = 0.01) and (4) upper to lower body flow distribution trend related to the weight (r = 0.742, p < 0.001) similar to the controls. Conclusions 4D velocity acquisition is reliable, operator-independent and more time-efficient than 2D flow acquisition to quantify SPCF. There is considerable SPCF in BCPC and Fontan patients. SPCF was more pronounced towards the respective lung with less pulmonary arterial flow suggesting more collateral flow where less anterograde branch pulmonary artery perfusion.
dc.fuente.origenBiomed Central
dc.identifier.citationJournal of Cardiovascular Magnetic Resonance. 2012 Apr 27;14(1):25
dc.identifier.doi10.1186/1532-429X-14-25
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26583
dc.identifier.wosidWOS:000308554300001
dc.issue.numeroNo. 25
dc.language.isoen
dc.pagina.final11
dc.pagina.inicio1
dc.revistaJournal of Cardiovascular Magnetic Resonancees_ES
dc.rightsacceso restringido
dc.rights.holderValverde et al.; licensee BioMed Central Ltd.
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.subject.otherPulmones - Enfermedadeses_ES
dc.subject.otherTécnicas de diagnóstico cardiovascular - Fisiologíaes_ES
dc.subject.otherDiagnóstico por imagenes_ES
dc.subject.otherResonancia magnéticaes_ES
dc.titleSystemic-to-pulmonary collateral flow in patients with palliated univentricular heart physiology: measurement using cardiovascular magnetic resonance 4D velocity acquisitiones_ES
dc.typeartículo
dc.volumenVol. 14
sipa.codpersvinculados16572
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