Association between proinsulin, insulin, proinsulin/insulin ratio, and insulin resistance status with the metabolic syndrome

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dc.contributor.authorPivatto, Ivana
dc.contributor.authorBustos, Patricia
dc.contributor.authorAmigo, Hugo
dc.contributor.authorAcosta, Ana Maria
dc.contributor.authorArteaga, Antonio
dc.date.accessioned2025-01-21T01:05:23Z
dc.date.available2025-01-21T01:05:23Z
dc.date.issued2007
dc.description.abstractThe Metabolic Syndrome (MS) constitutes an independent risk factor of cardiovascular disease. There is evidence that proinsulin blood levels and the proinsulin/insulin ratio are associated to the MS. The purpose of this study was to compare proinsulin and insulin, insulin resistance index, and the proinsulin/insulin ratio as predictors of MS. This is a cross-sectional study involving 440 men and 556 women with a mean age of 24 years. Diagnosis of MS was made according to the National Cholesterol Education Program Adult Treatment Panel III. Blood levels of insulin and proinsulin were measured, and the insulin resistance status was estimated using the homeostatic model assessment (HOMA-IR). The prevalence of MS was 10.1%. HOMA-IR was the best MS risk factor for both women and men (OR = 2.04; 95% CI: 1.68-2.48 and 1.09; 95% CI: 1.05-1.13, respectively). HOMA-IR presented the best positive predictive value for MS: 22% and 36% for men and women, respectively, and was the best MS indicator. The proinsulin/insulin ratio did not show significant association with MS. HOMA-IR, proinsulin, and insulin presented good negative predictive values for both genders that could be used to identify an at-risk population.
dc.fuente.origenWOS
dc.identifier.eissn1677-9487
dc.identifier.issn0004-2730
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95903
dc.identifier.wosidWOS:000256343600016
dc.issue.numero7
dc.language.isoen
dc.pagina.final1133
dc.pagina.inicio1128
dc.revistaArquivos brasileiros de endocrinologia e metabologia
dc.rightsacceso restringido
dc.subjectmetabolic syndrome
dc.subjectproinsulin
dc.subjectinsulin
dc.subjectinsulin resistance
dc.subjectHOMA-IR
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAssociation between proinsulin, insulin, proinsulin/insulin ratio, and insulin resistance status with the metabolic syndrome
dc.typeartículo
dc.volumen51
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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