Aortic Stenosis and Acquired von Willebrand Disease: Lack of Association

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dc.contributor.authorCarrasco, Esperanza
dc.contributor.authorLopez, Rodrigo
dc.contributor.authorRattalino, Marcos
dc.contributor.authorLema, Guillermo
dc.contributor.authorPereira, Jaime
dc.contributor.authorCanessa, Roberto
dc.contributor.authorZalaquett, Ricardo
dc.contributor.authorCarvajal, Claudia
dc.contributor.authorCarrasco, Paulo
dc.date.accessioned2024-01-10T13:11:09Z
dc.date.available2024-01-10T13:11:09Z
dc.date.issued2011
dc.description.abstractObjectives: The association between aortic stenosis (AS) and acquired von Willebrand disease type 2A has been described. It may be present in up to 90% of patients with AS. Shear stress has been proposed as the underlying mechanism; however, the physiopathology of this condition is not completely understood. No specific treatment has been studied in this specific population besides aortic valve replacement (AVR). As a coadjuvant therapy, some cardiac surgery centers use desmopressin routinely. The authors report the first stage of an ongoing study designed to compare the effects of desmopressin versus placebo in patients with severe AS scheduled for AVR. Because of the different incidences of the acquired von Willebrand type 2A reported in the literature, the first stage was conducted to describe the incidence of this clinical association in the present population, allowing the sample size for the second stage of the study to be obtained.
dc.description.abstractDesign: A prospective cohort study.
dc.description.abstractSetting: A single academic medical center.
dc.description.abstractParticipants: Thirteen patients with severe AS scheduled for AVR.
dc.description.abstractIntervention: None.
dc.description.abstractMeasurements and Main Results: Patients with severe AS scheduled for AVR were studied preoperatively with a von Willebrand laboratory panel. Results were negative for acquired von Willebrand disease type 2A in all patients. The second stage of the trial was stopped.
dc.description.abstractConclusion: Contrary to previous reports, no correlation was found between AS and acquired von Willebrand disease type 2A. Further studies are needed to ascertain whether this lack of association is caused by a specific characteristic of the present population, the small sample size, or other factors. (C) 2011 Elsevier Inc. All rights reserved.
dc.fechaingreso.objetodigital2024-04-25
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1053/j.jvca.2011.02.011
dc.identifier.issn1053-0770
dc.identifier.pubmedidMEDLINE:21493091
dc.identifier.urihttps://doi.org/10.1053/j.jvca.2011.02.011
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78005
dc.identifier.wosidWOS:000294793800003
dc.information.autorucMedicina;Canessa R ;S/I;55800
dc.information.autorucMedicina;Carrasco P ;S/I;69695
dc.information.autorucMedicina;Carvajal C ;S/I;1002822
dc.information.autorucMedicina;Lema G ;S/I;99835
dc.information.autorucMedicina;Lopez R ;S/I;15192
dc.information.autorucMedicina;Pereira J ;S/I;99371
dc.information.autorucMedicina;Rattalino M ;S/I;120801
dc.information.autorucMedicina;Zalaquett R ;S/I;100042
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final618
dc.pagina.inicio615
dc.publisherW B SAUNDERS CO-ELSEVIER INC
dc.revistaJOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
dc.rightsacceso restringido
dc.subjectvon Willebrand disease
dc.subjectaortic stenosis
dc.subjectcardiac surgery
dc.subjectSHEAR-STRESS
dc.subjectVALVE STENOSIS
dc.subjectANGIODYSPLASIA
dc.subjectDESMOPRESSIN
dc.subjectSURGERY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAortic Stenosis and Acquired von Willebrand Disease: Lack of Association
dc.typeartículo
dc.volumen25
sipa.codpersvinculados55800
sipa.codpersvinculados69695
sipa.codpersvinculados1002822
sipa.codpersvinculados99835
sipa.codpersvinculados15192
sipa.codpersvinculados99371
sipa.codpersvinculados120801
sipa.codpersvinculados100042
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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