Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes

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dc.contributor.authorNavarro, Paola
dc.contributor.authorChiong, Mario
dc.contributor.authorVolkwein, Karen
dc.contributor.authorMoraga, Francisco
dc.contributor.authorOcaranza, Maria Paz
dc.contributor.authorJalil, Jorge E.
dc.contributor.authorLim, Sun Woo
dc.contributor.authorKim, Jeong Ah
dc.contributor.authorKwon, H. Moo
dc.contributor.authorLavandero, Sergio
dc.date.accessioned2024-01-10T13:15:59Z
dc.date.available2024-01-10T13:15:59Z
dc.date.issued2008
dc.description.abstractChanges in cardiac osmolarity occur in myocardial infarction. Osmoregulatory mechanism may, therefore, play a Crucial role in cardiomyocyte survival. Tonicity-responsive enhancer binding protein (TonEBP) is a key transcription factor participating in the adaptation of cells to increases in tonicity. However, it is unknown whether cardiac TonEBP is activated by tonicity. Hypertonicity activated transcriptional activity of TonEBP, increased the amounts of both TonEBP mRNA and protein, and induced both the mRNA and protein of TonEBP target genes (aldose reductase and heat shock protein-70). Hypotonicity decreased the amount of TonEBP protein indicating bidirectional osmoregulation of this transcription factor. Adenoviral expression of a dominant negative TonEBP suppressed the hypertonicity-dependent increase of aldose reductase protein. These results indicated that TonEBP controls osmoregulatory mechanisms in cardiomyocytes. (C) 2008 Elsevier Inc. All rights reserved.
dc.description.funderNIDDK NIH HHS
dc.description.funderNATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
dc.fechaingreso.objetodigital20-03-2024
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.bbrc.2008.05.067
dc.identifier.issn0006-291X
dc.identifier.pubmedidMEDLINE:18502201
dc.identifier.urihttps://doi.org/10.1016/j.bbrc.2008.05.067
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78548
dc.identifier.wosidWOS:000256941000010
dc.information.autorucMedicina;Jalil J;S/I;99946
dc.information.autorucMedicina;Ocaranza M;S/I;1001254
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final330
dc.pagina.inicio326
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.revistaBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
dc.rightsacceso restringido
dc.subjectTonEBP
dc.subjectosmotic stress
dc.subjecttonicity
dc.subjectgene regulation
dc.subjectaldose reductase
dc.subjectcardiomyocytes
dc.subjectheart
dc.subjectSTRESS-RELATED GENES
dc.subjectSTIMULATES TRANSCRIPTION
dc.subjectEXPRESSION
dc.subjectNFAT5
dc.subjectHYPERTONICITY
dc.subjectVOLUME
dc.subjectHEART
dc.subjectOSMOLALITY
dc.subjectAPOPTOSIS
dc.subjectISCHEMIA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOsmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes
dc.typeartículo
dc.volumen372
sipa.codpersvinculados99946
sipa.codpersvinculados1001254
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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