Herpes simplex virus evasion of early host antiviral responses

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dc.article.number127
dc.catalogadorpva
dc.contributor.authorTognarelli Torres, Eduardo Ignacio
dc.contributor.authorPalomino Poblete, Tomás Francisco
dc.contributor.authorCorrales Bonilla, Nicolás
dc.contributor.authorBueno Ramírez, Susan
dc.contributor.authorKalergis Parra. Alexis Mikes
dc.contributor.authorGonzález Muñoz, Pablo Alberto
dc.date.accessioned2024-01-24T20:31:02Z
dc.date.available2024-01-24T20:31:02Z
dc.date.issued2019
dc.description.abstractHerpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) have co-evolved with humans for thousands of years and are present at a high prevalence in the population worldwide. HSV infections are responsible for several illnesses including skin and mucosal lesions, blindness and even life-threatening encephalitis in both, immunocompetent and immunocompromised individuals of all ages. Therefore, diseases caused by HSVs represent significant public health burdens. Similar to other herpesviruses, HSV-1 and HSV-2 produce lifelong infections in the host by establishing latency in neurons and sporadically reactivating from these cells, eliciting recurrences that are accompanied by viral shedding in both, symptomatic and asymptomatic individuals. The ability of HSVs to persist and recur in otherwise healthy individuals is likely given by the numerous virulence factors that these viruses have evolved to evade host antiviral responses. Here, we review and discuss molecular mechanisms used by HSVs to evade early innate antiviral responses, which are the first lines of defense against these viruses. A comprehensive understanding of how HSVs evade host early antiviral responses could contribute to the development of novel therapies and vaccines to counteract these viruses.
dc.description.funderVRAID (ex DIPUC)
dc.fechaingreso.objetodigital2024-01-24
dc.fuente.origenHistorial Académico
dc.identifier.citationTognarelli Torres Eduardo Igna, Bueno Ramirez Susan Marcela, Kalergis Parra Alexis Mikes, Gonzalez Munoz Pablo Alberto. Herpes Simplex Virus Evasion of Early Host Antiviral Responses. 2019;9:1-24.
dc.identifier.doi10.3389/fcimb.2019.00127
dc.identifier.issn2235-2988
dc.identifier.urihttps://doi.org/10.3389/fcimb.2019.00127
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80946
dc.identifier.wosidWOS:000466523600001
dc.information.autorucFacultad de Ciencias Biológicas; Tognarelli Torres, Eduardo Ignacio; S/I; 195523
dc.information.autorucFacultad de Ciencias Biológicas; Palomino Poblete, Tomás Francisco; S/I; 215423
dc.information.autorucFacultad de Ciencias Biológicas; Corrales Bonilla, Nicolás; S/I; 247402
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan; 0000-0002-7551-8088; 113541
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra. Alexis Mikes; 0000-0001-7622-5263; 90610
dc.information.autorucFacultad de Ciencias Biológicas; González Muñoz, Pablo Alberto; 0000-0001-7709-6870; 15616
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final24
dc.pagina.inicio1
dc.revistaFrontiers in Cellular and Infection Microbiologyes_ES
dc.rightsacceso abierto
dc.rights.licenseCreative Commons Attribution License (CC BY)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectInterferon (IFN)es_ES
dc.subjectInflammasomees_ES
dc.subjectToll-like receptors (TLRs)es_ES
dc.subjectNatural killer cells (NK cells)es_ES
dc.subjectDendritic cells (DCs)es_ES
dc.subjectCytosolic nucleic acid receptorses_ES
dc.subjectInnate immunityes_ES
dc.subjectApoptosises_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHerpes simplex virus evasion of early host antiviral responseses_ES
dc.typeartículo de revisión
dc.volumen9
sipa.codpersvinculados195523
sipa.codpersvinculados215423
sipa.codpersvinculados247402
sipa.codpersvinculados113541
sipa.codpersvinculados90610
sipa.codpersvinculados15616
sipa.trazabilidadHistorial Académico;09-07-2021
sipa.trazabilidadORCID;2024-01-15
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