Cortico-Hippocampal Oscillations Are Associated With the Developmental Onset of Hippocampal-Dependent Memory

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dc.contributor.authorGarcia-Perez, Maria A.
dc.contributor.authorIrani, Martin
dc.contributor.authorTiznado, Vicente
dc.contributor.authorBustamante, Tamara
dc.contributor.authorInostroza, Marion
dc.contributor.authorMaldonado, Pedro E.
dc.contributor.authorValdes, Jose L.
dc.date.accessioned2025-01-20T21:04:15Z
dc.date.available2025-01-20T21:04:15Z
dc.date.issued2022
dc.description.abstractHippocampal-dependent memories emerge late during postnatal development, aligning with hippocampal maturation. During sleep, the two-stage memory formation model states that through hippocampal-neocortical interactions, cortical slow-oscillations (SO), thalamocortical Spindles, and hippocampal sharp-wave ripples (SWR) are synchronized, allowing for the consolidation of hippocampal-dependent memories. However, evidence supporting this hypothesis during development is still lacking. Therefore, we performed successive object-in-place tests during a window of memory emergence and recorded in vivo the occurrence of SO, Spindles, and SWR during sleep, immediately after the memory encoding stage of the task. We found that hippocampal-dependent memory emerges at the end of the 4th postnatal week independently of task overtraining. Furthermore, we observed that those animals with better performance in the memory task had increased Spindle density and duration and lower density of SWR. Moreover, we observed changes in the SO-Spindle and Spindle-SWR temporal-coupling during this developmental period. Our results provide new evidence for the onset of hippocampal-dependent memory and its relationship to the oscillatory phenomenon occurring during sleep that helps us understand how memory consolidation models fit into the early stages of postnatal development.
dc.fuente.origenWOS
dc.identifier.doi10.3389/fnins.2022.891523
dc.identifier.eissn1662-453X
dc.identifier.urihttps://doi.org/10.3389/fnins.2022.891523
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93226
dc.identifier.wosidWOS:000827234100001
dc.language.isoen
dc.revistaFrontiers in neuroscience
dc.rightsacceso restringido
dc.subjecthippocampus
dc.subjectpostnatal
dc.subjectmemory
dc.subjectsleep
dc.subjectelectrophysiology
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCortico-Hippocampal Oscillations Are Associated With the Developmental Onset of Hippocampal-Dependent Memory
dc.typeartículo
dc.volumen16
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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