Clinical characteristics and outcomes of people living with HIV hospitalized with COVID-19: a nationwide experience

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dc.catalogadorpau
dc.contributor.authorCeballos, Maria Elena
dc.contributor.authorRoss, Patricio
dc.contributor.authorLasso, Martin
dc.contributor.authorDominguez, Isabel
dc.contributor.authorPuente, Marcela
dc.contributor.authorValenzuela, Pablo
dc.contributor.authorEnberg, Margarita
dc.contributor.authorSerri, Michel
dc.contributor.authorMuñoz, Rodrigo
dc.contributor.authorPinos, Yazmin
dc.contributor.authorSilva, Macarena
dc.contributor.authorNoguera, Matías
dc.contributor.authorDomínguez, Angélica
dc.contributor.authorZamora, Francisco
dc.contributor.otherChilean HIV/COVID-19 Study Group
dc.date.accessioned2024-03-06T14:05:52Z
dc.date.available2024-03-06T14:05:52Z
dc.date.issued2021
dc.description.abstractIn this prospective, multicentric, observational study, we describe the clinical characteristics and outcomes of people living with HIV (PLHIV) requiring hospitalization due to COVID-19 in Chile and compare them with Chilean general population admitted with SARS-CoV-2. Consecutive PLHIV admitted with COVID-19 in 23 hospitals, between 16 April and 23 June 2020, were included. Data of a temporally matched-hospitalized general population were used to compare demography, comorbidities, COVID-19 symptoms, and major outcomes. In total, 36 PLHIV subjects were enrolled; 92% were male and mean age was 44 years. Most patients (83%) were on antiretroviral therapy; mean CD4 count was 557 cells/mm3. Suppressed HIV viremia was found in 68% and 56% had, at least, one comorbidity. Severe COVID-19 occurred in 44.4%, intensive care was required in 22.2%, and five patients died (13.9%). No differences were seen between recovered and deceased patients in CD4 count, HIV viral load, or time since HIV diagnosis. Hypertension and cardiovascular disease were associated with a higher risk of death ( p = 0.02 and 0.006, respectively). Compared with general population, the HIV cohort had significantly more men (OR 0.15; IC 95% 0.07–0.31) and younger age (OR 8.68; IC 95% 2.66–28.31). In PLHIV, we found more intensive care unit admission (OR 2.31; IC 95% 1.05–5.07) but no differences in the need for mechanical ventilation or death. In this cohort of PLHIV hospitalized with COVID-19, hypertension and cardiovascular comorbidities, but not current HIV viro-immunologic status, were the most important risk factors for mortality. No differences were found between PLHIV and general population in the need for mechanical ventilation and death.
dc.fechaingreso.objetodigital2024-03-05
dc.fuente.origenORCID
dc.identifier.doi10.1177/0956462420973106
dc.identifier.urihttp://dx.doi.org/10.1177/0956462420973106
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84245
dc.information.autorucEscuela de Medicina; Domínguez, Angélica; 0000-0001-7477-7574; 131798
dc.language.isoen
dc.nota.accesoContenido parcial
dc.rightsacceso restringido
dc.titleClinical characteristics and outcomes of people living with HIV hospitalized with COVID-19: a nationwide experience
dc.typeartículo
sipa.codpersvinculados131798
sipa.trazabilidadORCID;2024-01-15
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