Growth of Very Low Birth Weight Infants Who Received a Liquid Human Milk Fortifier: A Randomized, Controlled Multicenter Trial

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dc.catalogadorpau
dc.contributor.authorMasoli, Daniela
dc.contributor.authorMena, Patricia
dc.contributor.authorDomínguez, Angélica
dc.contributor.authorRamolfo, Pamela
dc.contributor.authorVernal, Patricia
dc.contributor.authorPantoja, Miguel Angel
dc.contributor.authorEsparza, Ruth
dc.contributor.authorHübner, Maria Eugenia
dc.contributor.authorRíos, Antonio
dc.contributor.authorFaunes, Miriam
dc.contributor.authorUauy, Ricardo
dc.contributor.authorTapia, Jose L.
dc.contributor.otherNeocosur Network
dc.date.accessioned2024-03-06T14:05:52Z
dc.date.available2024-03-06T14:05:52Z
dc.date.issued2022
dc.description.abstractObjectives: To evaluate growth (weight, length, head circumference, and knee–heel length [KHL]) in very low birth weight (VLBW) infants (500–1500 g) who received human milk with a liquid fortifier (LHMF) with high protein and fatty acid content versus a traditional powder fortifier (PHMF) for 45 days or until discharge. Methods: This was a multicenter, randomized, controlled trial. An intention-to-treat analysis was performed to determine adverse events and withdrawal causes. We also performed an efficacy analysis involving the infants who completed at least 2 weeks of study. Results: Of the 158 infants enrolled in the study, 146 completed at least 2 weeks, and 125 completed the entire study. The biodemographic characteristics were similar between groups, with no differences in increments of weight (22.9 vs 22.7 g kg−1 day−1), length (1.03 vs 1.09 cm/week), head circumference (0.91 vs 0.90 cm/week), or KHL (3.6 vs 3.3 mm/week). The KHL increment was greater in infants weighing >1 kg receiving LHMF (3.7 vs 3.2 mm/week, P = 0.027). Although there were no significant differences in serious adverse events, the incidence difference of the composite outcome death/necrotizing enterocolitis between groups warrants attention (1.3% with LHMF and 8.1% with PHMF). Conclusion: There were no differences in the overall growth between VLBW infants receiving either fortifier.
dc.fechaingreso.objetodigital2024-11-14
dc.fuente.origenORCID
dc.identifier.doi10.1097/mpg.0000000000003321
dc.identifier.urihttp://dx.doi.org/10.1097/mpg.0000000000003321
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84244
dc.identifier.wosidWOS:000761954400024
dc.information.autorucEscuela de Medicina; Domínguez, Angélica; 0000-0001-7477-7574; 131798
dc.language.isoen
dc.nota.accesocontenido parcial
dc.rightsacceso restringido
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGrowth of Very Low Birth Weight Infants Who Received a Liquid Human Milk Fortifier: A Randomized, Controlled Multicenter Trial
dc.typeartículo
sipa.codpersvinculados131798
sipa.trazabilidadORCID;2024-01-15
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