Nature and extent of gastric lesions in symptomatic Chilean children with Helicobacter pylori-associated gastritis

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dc.contributor.authorGuiraldes, E
dc.contributor.authorPena, A
dc.contributor.authorDuarte, I
dc.contributor.authorTrivino, X
dc.contributor.authorSchultz, M
dc.contributor.authorLarrain, F
dc.contributor.authorEspinosa, MN
dc.contributor.authorHarris, P
dc.date.accessioned2024-01-10T12:40:46Z
dc.date.available2024-01-10T12:40:46Z
dc.date.issued2002
dc.description.abstractChile has one of the highest rates of gastric cancer in the world and most children and adolescents in the country are colonized by Helicobacter pylori. This study assessed the nature and extent of the gastric lesions in 73 consecutive patients aged 5-17 y, referred for upper gastrointestinal endoscopy. Their H. pylori-associated gastric pathology was characterized and these data were compared with their sociodemographic status. Endoscopic assessment was normal in 43 patients while in 30 there was a variety of mucosal lesions. Sixty patients (83%) had histological chronic gastritis of the antrum and in 45 (63%) the lesions also involved the gastric corpus; 90% of patients with chronic gastritis were colonized by H. pylori. Although most of these patients had epithelial erosions and dedifferentiation of the pit epithelium, atrophy and metaplasia were not found. Patients' socioeconomic status was inversely correlated with their rate of colonization by H. pylori (p < 0.005), the frequency of gastric lesions on endoscopy (p < 0.01) and the frequency of involvement of antral and corpus mucosa by chronic gastritis (p < 0.002). This latter feature was positively correlated with age (p < 0.001).
dc.description.abstractConclusion: This study shows a high frequency of extensive lesions of H. pylori-associated chronic gastritis in young Chilean patients. This histological picture is consistent with the hypothesis of a H. pylori-associated progressive gastric pathology which may represent a major factor in the high local rate of gastric cancer.
dc.fechaingreso.objetodigital2024-05-09
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1080/080352502753457923
dc.identifier.eissn1651-2227
dc.identifier.issn0803-5253
dc.identifier.pubmedidMEDLINE:11883816
dc.identifier.urihttps://doi.org/10.1080/080352502753457923
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77347
dc.identifier.wosidWOS:000173762500009
dc.information.autorucMedicina;Guiraldes E;S/I;98921
dc.information.autorucMedicina;Harris P;S/I;80706
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final44
dc.pagina.inicio39
dc.publisherWILEY
dc.revistaACTA PAEDIATRICA
dc.rightsacceso restringido
dc.subjectchildren
dc.subjectChilean
dc.subjectgastritis
dc.subjectgastric cancer
dc.subjectHelicobacter pylori
dc.subjectCANCER
dc.subjectEPIDEMIOLOGY
dc.subjectPREVALENCE
dc.subjectINFECTION
dc.subjectDISEASE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNature and extent of gastric lesions in symptomatic Chilean children with Helicobacter pylori-associated gastritis
dc.typeartículo
dc.volumen91
sipa.codpersvinculados98921
sipa.codpersvinculados80706
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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