Epigenetics: New Concepts of Old Phenomena in Vascular Physiology

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dc.contributor.authorKrause, Bernardo
dc.contributor.authorSobrevia, Luis
dc.contributor.authorCasanello, Paola
dc.date.accessioned2024-01-10T12:38:44Z
dc.date.available2024-01-10T12:38:44Z
dc.date.issued2009
dc.description.abstractThe hypothesis of 'Developmental Origins of Health and Disease' (DOHaD) relies on the presence of mechanisms sensing and signalling a diversity of stimuli during fetal development. The mechanisms that have been broadly suggested to be involved in these processes are the epigenetic modifications that could 'record' perinatal stimuli. Since the definition of epigenetic and the associated mechanisms are conflictive, in this review epigenetic was defined as 'chromosome-based mechanisms that can change the phenotypic plasticity in a cell or organism'. The most understood epigenetic mechanisms (i.e. DNA methylation, histone post-translational modifications (PTM), ATP-dependent chromatin modifications and non-coding RNAs) and reported evidence for their role in fetal programming were briefly reviewed.
dc.description.abstractThe development of the vascular system is strongly influenced by epigenetic mechanisms. For that reason vascular cells are good candidates to be explored regarding epigenetic programming since its proved susceptibility to be imprinted. This has been described in pregnancy diseases such as intra-uterine growth restriction, gestational diabetes and pre-eclampsia, where changes in vascular function are preserved in vitro.
dc.description.funderFondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT)
dc.description.funderCONICYT
dc.fechaingreso.objetodigital2024-05-17
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.2174/157016109789043883
dc.identifier.eissn1875-6212
dc.identifier.issn1570-1611
dc.identifier.pubmedidMEDLINE:19485890
dc.identifier.urihttps://doi.org/10.2174/157016109789043883
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77091
dc.identifier.wosidWOS:000269248200010
dc.information.autorucMedicina;Casanello P;S/I;146772
dc.information.autorucMedicina;Krause B;S/I;1005678
dc.information.autorucMedicina;Sobrevia L;S/I;1002656
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final520
dc.pagina.inicio513
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.revistaCURRENT VASCULAR PHARMACOLOGY
dc.rightsacceso restringido
dc.subjectEpigenetics
dc.subjecthuman
dc.subjectendothelium
dc.subjectsmooth muscle cell
dc.subjectvascular
dc.subjectNITRIC-OXIDE SYNTHASE
dc.subjectALTERED GENE-EXPRESSION
dc.subjectSMOOTH-MUSCLE-CELLS
dc.subjectHISTONE DEACETYLASES
dc.subjectENDOTHELIAL-CELLS
dc.subjectDNA METHYLATION
dc.subjectDEVELOPMENTAL ORIGINS
dc.subjectIN-VITRO
dc.subjectGROWTH
dc.subjectDIFFERENTIATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEpigenetics: New Concepts of Old Phenomena in Vascular Physiology
dc.typeartículo
dc.volumen7
sipa.codpersvinculados146772
sipa.codpersvinculados1005678
sipa.codpersvinculados1002656
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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