Do corticosteroids affect lumbar spinal fusion? A rabbit model using high-dose methylprednisolone

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dc.contributor.authorUrrutia, Julio
dc.contributor.authorCarmona, Maximiliano
dc.contributor.authorBriceno, Jorge
dc.date.accessioned2024-01-10T13:47:40Z
dc.date.available2024-01-10T13:47:40Z
dc.date.issued2011
dc.description.abstractThe effect of corticosteroids on spinal fusion healing has not yet been determined. To evaluate the effect of corticosteroids on lumbar spinal fusion we designed a randomized, placebo-controlled animal study using high-dose methylprednisolone sodium succinate, which is widely used in patients with spinal cord injury who are undergoing spinal fusion.
dc.description.abstractTwo groups of 18 rabbits underwent a postero-lateral fusion at L5-L6 with autologous bone graft. After surgery, the animals were assigned to receive: (a) methylprednisolone sodium succinate 30 mg/kg over 15 min, followed by an intravenous infusion of 5.4 mg/kg/h for 23 h, or (b) normal saline in the same volume. Animals were killed 8 weeks after surgery; the presence of fusion was analyzed by use of two different methods: a manual palpation test and an antero-posterior radiograph.
dc.description.abstractBoth groups of animals were comparable in weight. Fusion was achieved in 5/18 rabbits (27.8%) in the methylprednisolone group and in 9/18 animals (50%) in the control group (p = 0.17).
dc.description.abstractIn a lumbar posterolateral fusion rabbit model, high-dose methylprednisolone sodium succinate reduced the success of lumbar fusion; however, our data did not reach statistical significance.
dc.fechaingreso.objetodigital2024-03-19
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00776-011-0061-3
dc.identifier.issn0949-2658
dc.identifier.pubmedidMEDLINE:21528390
dc.identifier.urihttps://doi.org/10.1007/s00776-011-0061-3
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79293
dc.identifier.wosidWOS:000293001600016
dc.information.autorucMedicina;Briceno J ;S/I;175098
dc.information.autorucMedicina;Carmona M ;S/I;119775
dc.information.autorucMedicina;Urrutia J ;S/I;69910
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final442
dc.pagina.inicio439
dc.publisherSPRINGER TOKYO
dc.revistaJOURNAL OF ORTHOPAEDIC SCIENCE
dc.rightsacceso restringido
dc.subjectBONE MORPHOGENETIC PROTEIN-2
dc.subjectCORD-INJURY
dc.subjectEARLY COMPLICATIONS
dc.subjectSODIUM SUCCINATE
dc.subjectGLUCOCORTICOIDS
dc.subjectSPONDYLOLISTHESIS
dc.subjectCORTISONE
dc.subjectTHERAPY
dc.subjectPSEUDOARTHROSIS
dc.subjectINSTRUMENTATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDo corticosteroids affect lumbar spinal fusion? A rabbit model using high-dose methylprednisolone
dc.typeartículo
dc.volumen16
sipa.codpersvinculados175098
sipa.codpersvinculados119775
sipa.codpersvinculados69910
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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