Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor

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dc.contributor.authorSlutsky, Rebecca
dc.contributor.authorRomero, Roberto
dc.contributor.authorXu, Yi
dc.contributor.authorGalaz, Jose
dc.contributor.authorMiller, Derek
dc.contributor.authorDone, Bogdan
dc.contributor.authorTarca, Adi L.
dc.contributor.authorGregor, Sabrina
dc.contributor.authorHassan, Sonia S.
dc.contributor.authorLeng, Yaozhu
dc.contributor.authorGomez-Lopez, Nardhy
dc.date.accessioned2025-01-23T21:13:08Z
dc.date.available2025-01-23T21:13:08Z
dc.date.issued2019
dc.description.abstractSuccessful pregnancy requires a tightly-regulated equilibrium of immune cell interactions at the maternal-fetal interface (i.e., the decidual tissues), which plays a central role in the inflammatory process of labor. Most of the innate immune cells in this compartment have been well characterized; however, adaptive immune cells are still under investigation. Herein, we performed immunophenotyping of the decidua basalis and decidua parietalis to determine whether exhausted and senescent T cells are present at the maternal-fetal interface and whether the presence of pathological (i.e., preterm) or physiological (i.e., term) labor and/or placental inflammation alter such adaptive immune cells. In addition, decidual exhausted T cells were sorted to test their functional status. We found that (1) exhausted and senescent T cells were present at the maternal-fetal interface and predominantly expressed an effector memory phenotype, (2) exhausted CD4(+) T cells increased in the decidua parietalis as gestational age progressed, (3) exhausted CD4(+) and CD8(+) T cells decreased in the decidua basalis of women who underwent labor at term compared to those without labor, (4) exhausted CD4(+) T cells declined with the presence of placental inflammation in the decidua basalis of women with preterm labor, (5) exhausted CD8(+) T cells decreased with the presence of placental inflammation in the decidua basalis of women who underwent labor at term, (6) both senescent CD4(+) and CD8(+) T cells declined with the presence of placental inflammation in the decidua basalis of women who underwent preterm labor, and (7) decidual exhausted T cells produced IFN and TNF upon in vitro stimulation. Collectively, these findings indicate that exhausted and senescent T cells are present at the human maternal-fetal interface and undergo alterations in a subset of women either with labor at term or preterm labor and placental inflammation. Importantly, decidual T cell function can be restored upon stimulation.
dc.fuente.origenWOS
dc.identifier.doi10.1155/2019/3128010
dc.identifier.eissn2314-7156
dc.identifier.issn2314-8861
dc.identifier.urihttps://doi.org/10.1155/2019/3128010
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100991
dc.identifier.wosidWOS:000470181200001
dc.language.isoen
dc.revistaJournal of immunology research
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor
dc.typeartículo
dc.volumen2019
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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