Addition of long‐acting beta‐agonists to inhaled corticosteroids for asthma in preschool children: A systematic review

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dc.catalogadorvzp
dc.contributor.authorAmbrozej, Dominika
dc.contributor.authorCieslik, Cieslik
dc.contributor.authorFeleszko, Wojciech
dc.contributor.authorRodriguez-Martinez, Carlos E.
dc.contributor.authorCastro Rodríguez, José Antonio
dc.date.accessioned2025-03-12T13:26:49Z
dc.date.available2025-03-12T13:26:49Z
dc.date.issued2024
dc.description.abstractInhaled corticosteroids (ICS) and long-acting beta-agonists (LABA) are essential in asthma management, but the guidelines for treatment in preschool children remain heterogeneous worldwide. This systematic review evaluates the efficacy and safety of LABA + ICS therapy in asthmatic children under six years. We searched four databases, identifying six eligible studies (n = 1415 preschoolers), and in all the LABA used was salmeterol. Due to high heterogeneity, quantitative analysis was not feasible. Three before-and-after studies demonstrated significant reductions in unscheduled visits and hospitalizations due to asthma exacerbations with LABA + ICS. One RCT showed fewer exacerbations in the LABA + ICS group compared to ICS alone. Night-time awakenings decreased significantly in two studies but not in one RCT. Improvements in lung function using impulse oscillometry and FeNO levels were noted with LABA+ICS in one RCT. No significant adverse effects were reported. Despite positive findings, high-quality trials are needed to confirm these results, particularly using formoterol as LABA, aligning with the recommendations. Further research is imperative to optimize asthma management in preschool children.
dc.format.extent7 páginas
dc.fuente.origenSCOPUS
dc.identifier.doi10.1016/j.prrv.2024.09.002
dc.identifier.issn15260550 15260542
dc.identifier.issn1526-0542
dc.identifier.scopusidSCOPUS_ID:85208386117
dc.identifier.urihttps://doi.org/10.1016/j.prrv.2024.09.002
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102508
dc.information.autorucEscuela de Medicina; Castro Rodríguez, José Antonio; 0000-0002-0708-4281; 113247
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherW.B. Saunders Ltd
dc.revistaPaediatric Respiratory Reviews
dc.rightsacceso restringido
dc.subjectAsthma
dc.subjectChild
dc.subjectICS
dc.subjectLABA
dc.subjectPreschool
dc.subjectSystematic review
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAddition of long‐acting beta‐agonists to inhaled corticosteroids for asthma in preschool children: A systematic review
dc.typeartículo
sipa.codpersvinculados113247
sipa.trazabilidadSCOPUS;2024-11-17
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